Bacterial mutagenic evaluation of Luxabendazole, a new broad spectrum anthelmintic, with the Salmonella typhimurium His− and the Escherichia coli Tryp− reversion tests
| Autor: | M.Teresa Pollastrini, David Ordóñez, Ana I. Ortiz, Marta Barea |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Salmonella typhimurium Benzimidazole Carbamate Salmonella Health Toxicology and Mutagenesis medicine.medical_treatment Reversion In Vitro Techniques Biology Toxicology medicine.disease_cause Microbiology Ames test Rats Sprague-Dawley chemistry.chemical_compound Escherichia coli Genetics medicine Animals Humans Anthelmintic Biotransformation Genetics (clinical) Anthelmintics Mutagenicity Tests Rats chemistry Microsomes Liver Microsome Benzimidazoles Carbamates Mutagens medicine.drug |
| Zdroj: | Mutagenesis. 11:27-31 |
| ISSN: | 1464-3804 0267-8357 |
| DOI: | 10.1093/mutage/11.1.27 |
| Popis: | Luxabendazole is a new benzimidazole carbamate chemotherapeutic agent, which has proved to be effective against adult and immature stages of the major gastrointestinal nematodes, trematodes and cestodes. The mutagenic properties of Luxabendazole were investigated in the in vitro Ames Salmonella and E. coli tests. The product was tested at concentrations of 0.5, 5, 50, 500, 1250 and 2500 micrograms/plate in the TA1535, TA1538, TA98 and TA100 strains of Salmonella typhimurium, and 0.5, 5, 50 and 500 micrograms/plate in the WP2, WP2uvrA- and its pKM 101-containing derivative CM891 (WP2 uvrA- pKM101) strains of Escherichia coli, with and without S9 microsomal activation (post-mitochondrial liver fraction from Wistar rats pretreated with Aroclor(R)). Positive and negative controls were included in each experiment. From the present study it can be concluded that Luxabendazole, over a dose range of 0.5-2500 micrograms/plate, is unlikely to present a mutagenic hazard, as demonstrated by the Ames test. |
| Databáze: | OpenAIRE |
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