Serum phytanic and pristanic acid levels and prostate cancer risk in Finnish smokers

Autor: Demetrius Albanes, Stephanie J. Weinstein, Ann B. Moser, Kirk Snyder, Margaret E. Wright, Satu Männistö, Peter H. Gann
Rok vydání: 2014
Předmět:
Male
phytanic acid
Pristanic acid
Cancer Research
medicine.medical_specialty
Phytanic acid
Saturated fat
Gas Chromatography-Mass Spectrometry
03 medical and health sciences
Prostate cancer
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Internal medicine
Biomarkers
Tumor
Humans
Medicine
Radiology
Nuclear Medicine and imaging
Aged
Randomized Controlled Trials as Topic
Original Research
030304 developmental biology
2. Zero hunger
chemistry.chemical_classification
0303 health sciences
Cancer prevention
business.industry
Fatty Acids
Smoking
pristanic acid
Case-control study
Prostatic Neoplasms
Clinical Cancer Research
Fatty acid
Biomarker
Middle Aged
prostate cancer
medicine.disease
3. Good health
Endocrinology
Oncology
chemistry
Case-Control Studies
030220 oncology & carcinogenesis
Red meat
diet
business
Zdroj: Cancer Medicine
ISSN: 2045-7634
DOI: 10.1002/cam4.319
Popis: Phytanic acid is a saturated branched-chain fatty acid found predominantly in red meat and dairy products, and may contribute to the elevated risks of prostate cancer associated with higher consumption of these foods. Pristanic acid is formed during peroxisomal oxidation of phytanic acid, and is the direct substrate of α-Methyl-CoA-Racemase (AMACR)--an enzyme that is consistently overexpressed in prostate tumors relative to benign tissue. We measured phytanic and pristanic acids as percentages of total fatty acids by gas chromatography-mass spectrometry in prediagnostic blood samples from 300 prostate cancer cases and 300 matched controls, all of whom were participants in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study supplementation trial and follow-up cohort. In addition to providing a fasting blood sample at baseline, all men completed extensive diet, lifestyle, and medical history questionnaires. Among controls, the strongest dietary correlates of serum phytanic and pristanic acids were saturated fat, dairy fat, and butter (r = 0.50 and 0.40, 0.46 and 0.38, and 0.40 and 0.37, respectively; all P-values
Databáze: OpenAIRE
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