Advanced glycation end products (AGEs) in oral pathology
| Autor: | Jared Q. Gerlach, Anida Maria Băbţan, Nausica Bianca Petrescu, Aranka Ilea, Massimo Collino, Maria Crisan, Radu Septimiu Câmpian, Bianca Bosca, Rosa M. Sainz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Glycation End Products Advanced medicine.medical_specialty Periodontal pathology Advanced glycation end products - AGEs Chronic inflammation Diet-related disease Oral pathology Salivary biosensor Otorhinolaryngology2734 Pathology and Forensic Medicine Dentistry (all) Cell Biology Disease 03 medical and health sciences 0302 clinical medicine Glycation Internal medicine Oral and maxillofacial pathology medicine Animals Humans General Dentistry business.industry Dietary intake Stomatognathic Diseases 030206 dentistry General Medicine medicine.disease 030104 developmental biology Otorhinolaryngology Assessment methods Etiology Metabolic syndrome business |
| Zdroj: | Archives of oral biology. 93 |
| ISSN: | 1879-1506 |
| Popis: | Objective Maillard advanced glycation end products (AGEs) are connected with high dry temperature food processing, color and flavor modification of food products. Oral cavity pathology is strongly influenced by dietary intake. The aim of the present paper is to update current data regarding the sources and metabolism of AGEs, their impact on oral cavity tissues, to discuss and suggest new approaches for the early diagnosis and efficient treatment of AGEs-related oral pathology. Design This paper is a narrative review of the studies discussing AGEs and mainly the dietary AGEs (dAGEs) sources, metabolism, linkage to general diseases, and specifically the oral cavity pathology. The authors used "PUBMED" and MeSH for the finding of English written and published articles concerning AGEs. There were used the next keywords association: “advanced glycation end products- AGEs” AND “Maillard products”, “AGEs” AND “diet-related disease, “AGEs” AND “salivary biosensor”, “AGEs” AND “metabolic syndrome AGEs”, “AGEs” AND “oral pathology”, “AGEs” AND “dentin AGEs” OR “periodontal AGEs”, “AGEs” AND “diagnosis and monitoring”. The authors used free full-text articles to determine the etiology and physiopathology of AGEs, their association with general diseases and oral cavity disease, assessment methods used in biofluids and tissues, AGEs prevention and treatment approaches. Articles concerning AGEs etiology, metabolism and effect in the human body and specific implication in oral pathology were selected. There were no exclusion criteria in what concerns the study design. Studies in other language than English and articles abstracts were excluded. Criteria of inclusion were free full-text articles written in English. Equally human and animal model studies were included. Regarding the date of publication, all subjects concerning glycation products after 1953 (first published article) were included. Results Evidence show that AGEs are responsible for inducing low intensity chronic inflammation and thereby, for initiating and/or aggravating chronic diseases. Nowadays, research has demonstrated a significant association between AGEs and dental or periodontal pathology. Moreover, salivary AGEs are consistent with the levels of AGEs in other biological fluids and are correlated with the general and oral pathology. Conclusions Assessment of salivary AGEs could be a reliable tool for early diagnosis and monitoring diet-related disease. |
| Databáze: | OpenAIRE |
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