Copper-Catalyzed Decarboxylative/Click Cascade Reaction: Regioselective Assembly of 5-Selenotriazole Anticancer Agents
| Autor: | Shi-Xia Su, Fei-hu Cui, Yan-Yan Chen, Xian-Li Ma, Heng-Shan Wang, Ying-Ming Pan, Jing Chen, Hai-Tao Tang, Xu Yanli, Zu-Yu Mo |
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| Rok vydání: | 2018 |
| Předmět: |
Azides
Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry Regioselectivity chemistry.chemical_element Antineoplastic Agents Triazoles 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Catalysis In vitro 0104 chemical sciences Cascade reaction Alkynes Click chemistry Copper catalyzed MTT assay Physical and Theoretical Chemistry Selenium Compounds Copper Selenium |
| Zdroj: | Organic Letters. 20:925-929 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A simple and efficient Cu-catalyzed decarboxylative/click reaction for the preparation of 1,4-disubstituted 5-arylselanyl-1,2,3-triazoles from propiolic acids, diselenides, and azides has been developed. The mechanistic study revealed that the intermolecular AAC reaction of an alkynyl selenium intermediate occurred. The resulting multisubstituted 5-seleno-1,2,3-triazoles were tested for in vitro anticancer activity by MTT assay, and compounds 4f, 4h, and 4p showed potent cancer cell-growth inhibition activities. |
| Databáze: | OpenAIRE |
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