Effect of Cyclosporin A on Renal Cortical Resistances Measured by Color Doppler Flowmetry on Renal Grafts
| Autor: | F. Q. Di Palo, P. Palazzi, S. Zafiropulu, P. Abelli, A. Elli, R. Rivolta, C. Zanussi, D. Castagnone |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Kidney Cortex Urology Renal function Kidney urologic and male genital diseases Nephrotoxicity Nephropathy symbols.namesake Cyclosporin a medicine Humans Ultrasonography business.industry medicine.disease Kidney Transplantation Transplantation medicine.anatomical_structure Vasoconstriction Creatinine Renal blood flow Cyclosporine symbols Female Vascular Resistance business Doppler effect |
| Zdroj: | Nephron. 65:240-244 |
| ISSN: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000187481 |
| Popis: | Doppler spectra were recorded at different cyclosporin A (CSA) levels (trough and peak) in 30 stable renal-transplanted outpatients: 15 with unimpaired renal function (plasma creatinine150 mumol/l) and 15 with renal impairment (plasma creatinine 150-350 mumol/l). Pulsatility (PI) and resistive indexes (RI) have been measured in the renal artery at the hilum and in the renal cortex. RI and PI were markedly increased (p0.0001) in the cortex at peak time while in the renal artery no significant changes were observed. These variations were statistically related with CSA blood levels (PI = p0.02; r = 0.54, RI = p0.05; r = 0.45). These effects were also found in the presence of renal damage. CSA dose-dependently reduces cortical blood flow, causing a persistent arteriolar vasoconstriction and a reduction in diastolic flow. This effect can be measured in man in a noninvasive and repeatable way using color Doppler sonograms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|