Pegylated feline granulocyte colony-stimulating factor increases neutrophil levels in cats
| Autor: | Ezra N. Noon-Song, Janet K. Yamamoto, Shannon R. Roff, Taishi Tanabe, M.J. Offner, Y. Sakagawa, Jeffrey R. Abbott, Hirotaka Kondo, James K. Coleman, James G. Coisman |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Neutropenia Neutrophils Endogeny Immunodeficiency Virus Feline Gastroenterology Polyethylene Glycols Internal medicine Granulocyte Colony-Stimulating Factor PEG ratio medicine Animals Humans Adverse effect CATS General Veterinary biology business.industry medicine.disease Antibodies Neutralizing Recombinant Proteins Specific Pathogen-Free Organisms Granulocyte colony-stimulating factor Clinical trial Immunology Cats Lentivirus Infections biology.protein Female Animal Science and Zoology Antibody business |
| Zdroj: | The Veterinary Journal. 200:44-50 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2014.01.019 |
| Popis: | Neutropenia can often be corrected by treatment with granulocyte-colony stimulating factor (G-CSF) and off-label use of commercial human G-CSF (HuG-CSF) is a commonly used treatment for neutropenic animals. However, long-term HuG-CSF treatment can be associated with adverse effects, including neutropenia. Here, feline (Fe) G-CSF was produced in Pichia pastoris, pegylated (Peg) FeG-CSF and tested in cats. A randomized controlled clinical trial was conducted to evaluate the efficacy of PegFeG-CSF compared to FeG-CSF or HuG-CSF in FIV-infected (n=14), FIV-uninfected healthy cats (n=19), and in HuG-CSF-induced neutropenic cats (n=4). Daily FeG-CSF doses induced higher neutrophil production than HuG-CSF after the second week of treatment (P ⩽ 0.002). Weekly doses of PegFeG-CSF induced higher neutrophil counts and showed greater sustained activity than weekly doses of FeG-CSF. PegFeG-CSF provided the most therapeutic and sustainable neutrophil production (P |
| Databáze: | OpenAIRE |
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