Body temperature-dependent action of baclofen in rat stomach. Relation to acid secretion and ulcerogenicity
| Autor: | Hiromichi Niida, Koji Takeuchi, Hideyuki Nishiwaki, Susumu Okabe |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Atropine
Male medicine.medical_specialty Baclofen Physiology medicine.medical_treatment Gastric motility Motility Stimulation Deoxyglucose Vagotomy Body Temperature Gastric Acid Internal medicine medicine Animals Stomach Ulcer Chemistry Stomach Gastroenterology Rats Inbred Strains Gastric Acidity Determination Rats Endocrinology medicine.anatomical_structure Mechanism of action Duodenum medicine.symptom Gastrointestinal Motility medicine.drug |
| Zdroj: | Digestive diseases and sciences. 35(4) |
| ISSN: | 0163-2116 |
| Popis: | The effect of baclofen (PCPGABA) on acid secretion, motility, and mucosa was investigated in the anesthetized rat stomach under various body temperatures (BT: 28-38 degrees C), and they were compared with those of 2-deoxy-D-glucose (2DG), an acid stimulant through cytoglycopenia. Under these conditions PCPGABA induces lesions dose-dependently (greater than 1 mg/kg, subcutaneously) in both the stomach and duodenum, and this action was dependent on BT; lowering of BT enhanced the ulcerogenicity. PCPGABA (3 mg/kg) had no effect on acid secretion at higher BT (36-38 degrees C) but produced a marked increase of acid output at lower BT (30-32 degrees C). 2DG caused a stimulation of acid output and gastric lesions without BT dependency, but the duodenal ulcerogenicity enhanced at lower BT. Gastric motility was enhanced significantly by these two agents to similar degrees, at either high or low BT. Neither PCPGABA nor 2DG affected alkaline secretion in the duodenum, while lowering of BT by itself reduced alkaline secretory responses. The above changes caused by PCPGABA and 2DG were blocked by both atropine and vagotomy. These results suggest that (1) acid stimulatory and ulcerogenic action of PCPGABA may involve a temperature-dependent process but does not relate to a cytoglycopenia, and (2) the vagus nerve mediating acid secretion and motility may be different in the temperature dependency. |
| Databáze: | OpenAIRE |
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