Regulation of matrix metalloproteinases (type IV collagenases) and their inhibitors in the virgin, timed pregnant, and postpartum rat uterus and cervix by prostaglandin E(2)-cyclic adenosine monophosphate

Autor: Z.Yuelan Ren, Cecilia A. Lyons, Eileen Chang, Yasir Akmal, Kay Beharry, Michael P. Nageotte, Kenji C. Nishihara
Rok vydání: 2002
Předmět:
Zdroj: American journal of obstetrics and gynecology. 187(1)
ISSN: 0002-9378
Popis: Objective: Our purpose was to examine whether the type IV collagenases (metalloproteinase [MMP]-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) are regulated by a prostaglandin E 2 (PGE 2 )-cyclic adenosine monophosphate (cAMP) mechanism in nonpregnant virgin, preterm and term pregnant and postpartum rats. Study Design: Sprague-Dawley rats were infused with either saline solution or PGE 2 over 24 hours or were noninfused. Plasma and tissue were analyzed for cAMP, MMP-2 and MMP-9, and TIMP-1 and TIMP-2. Results: PGE 2 evoked elevations in plasma and tissue levels of cAMP and MMP-2 in the preterm and term pregnant rats. MMP-9 levels were elevated in the preterm plasma and uterus, whereas in the term pregnant and postpartum rats, MMP-9 levels were increased in the cervix. Conclusions: MMP levels in the pregnant and postpartum rat uterus and cervix are regulated in part by a PGE 2 -cAMP mechanism. Specifically, MMP-9 may be involved in preterm labor, cervical maturity, and involution of the postpartum uterus. (Am J Obstet Gynecol 2002;187:202-8.)
Databáze: OpenAIRE
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