Regulation of matrix metalloproteinases (type IV collagenases) and their inhibitors in the virgin, timed pregnant, and postpartum rat uterus and cervix by prostaglandin E(2)-cyclic adenosine monophosphate
Autor: | Z.Yuelan Ren, Cecilia A. Lyons, Eileen Chang, Yasir Akmal, Kay Beharry, Michael P. Nageotte, Kenji C. Nishihara |
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Rok vydání: | 2002 |
Předmět: |
Adenosine monophosphate
medicine.medical_specialty Matrix metalloproteinase inhibitor medicine.medical_treatment Uterus Cervix Uteri Matrix Metalloproteinase Inhibitors Dinoprostone Rats Sprague-Dawley chemistry.chemical_compound Pregnancy Internal medicine medicine Cyclic AMP Animals Cyclic adenosine monophosphate Prostaglandin E2 Cervix reproductive and urinary physiology Tissue Inhibitor of Metalloproteinase-2 Tissue Inhibitor of Metalloproteinase-1 business.industry Obstetrics and Gynecology Rats Endocrinology medicine.anatomical_structure chemistry Matrix Metalloproteinase 9 In utero Matrix Metalloproteinase 2 Female business Prostaglandin E medicine.drug |
Zdroj: | American journal of obstetrics and gynecology. 187(1) |
ISSN: | 0002-9378 |
Popis: | Objective: Our purpose was to examine whether the type IV collagenases (metalloproteinase [MMP]-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) are regulated by a prostaglandin E 2 (PGE 2 )-cyclic adenosine monophosphate (cAMP) mechanism in nonpregnant virgin, preterm and term pregnant and postpartum rats. Study Design: Sprague-Dawley rats were infused with either saline solution or PGE 2 over 24 hours or were noninfused. Plasma and tissue were analyzed for cAMP, MMP-2 and MMP-9, and TIMP-1 and TIMP-2. Results: PGE 2 evoked elevations in plasma and tissue levels of cAMP and MMP-2 in the preterm and term pregnant rats. MMP-9 levels were elevated in the preterm plasma and uterus, whereas in the term pregnant and postpartum rats, MMP-9 levels were increased in the cervix. Conclusions: MMP levels in the pregnant and postpartum rat uterus and cervix are regulated in part by a PGE 2 -cAMP mechanism. Specifically, MMP-9 may be involved in preterm labor, cervical maturity, and involution of the postpartum uterus. (Am J Obstet Gynecol 2002;187:202-8.) |
Databáze: | OpenAIRE |
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