Prognostic Impact of Postoperative C-reactive Protein for Non-small Cell Lung Cancer Following Lobectomy
| Autor: | Masaki Matsuo, Masakazu Sugaya, Shuichi Shinohara, Kazuhiko Machida, Fumihiro Tanaka, Takamitsu Onitsuka |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research medicine.medical_specialty Multivariate analysis Lung Neoplasms Kaplan-Meier Estimate Gastroenterology 03 medical and health sciences Internal medicine Carcinoma Non-Small-Cell Lung Overall survival Biomarkers Tumor Medicine Humans In patient Lung cancer Pneumonectomy Aged Proportional Hazards Models Retrospective Studies biology business.industry C-reactive protein Hazard ratio Cancer General Medicine Middle Aged medicine.disease Prognosis 030104 developmental biology C-Reactive Protein Oncology biology.protein Female Non small cell business |
| Zdroj: | Anticancer research. 38(5) |
| ISSN: | 1791-7530 |
| Popis: | BACKGROUND/AIM C-reactive protein (CRP) is associated with cancer progression; however, the prognostic impact of postoperative CRP remains controversial. The aim of this study was to investigate the prognostic significance of postoperative CRP in patients with resected non-small cell lung cancer (NSCLC). PATIENTS AND METHODS A total of 198 consecutive patients with NSCLC that had undergone lobectomy were retrospectively reviewed. CRP was measured on postoperative days 1, 3, and 5. Patients were divided into two groups according to the median of CRP on postoperative day 3 (CRP3); the high and low CRP3 groups (n=99, respectively). RESULTS Five-year overall survival was significantly higher in the high CRP3 group than the low CRP3 (75.3% vs. 86.5%; p=0.016), as was the 5-year recurrence-free survival (62.7% vs. 73.0%; p=0.016). Multivariate analysis revealed that high CRP3 was associated with a favorable prognosis (hazard ratio(HR)=0.36; p |
| Databáze: | OpenAIRE |
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