Nanoconstructs as a versatile tool for detection and diagnosis of Alzheimer biomarkers
| Autor: | Angel Treasa Alex, Sureshwar Pandey, Nayanabhirama Udupa, Guruprasad Kalthur, Srinivas Mutalik, Abhijeet Pandey, Divya Gopalan |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Oxide Nanoparticle Bioengineering Nanotechnology 02 engineering and technology Carbon nanotube 010402 general chemistry 01 natural sciences Silver nanoparticle law.invention Nanomaterials chemistry.chemical_compound Alzheimer Disease law Nanosensor Humans General Materials Science Electrical and Electronic Engineering Graphene Mechanical Engineering General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Mechanics of Materials Colloidal gold 0210 nano-technology Biomarkers |
| Zdroj: | Nanotechnology. 32:142002 |
| ISSN: | 1361-6528 0957-4484 |
| DOI: | 10.1088/1361-6528/abcdcb |
| Popis: | The current review focuses towards the advancements made in the past decade in the field of nanotechnology for the early Alzheimer’s disease (AD) diagnosis. This review includes the application of nanomaterials and nanosensors for the early detection of the main AD biomarkers (amyloid beta, phosphorylated tau, apolipoprotein E4 allele or APOE4, microRNAs, cholesterol, hydrogen peroxide etc) in biological fluids, to detect the biomarkers at a very low concentration ranging in pico, femto and even atto molar concentrations. The field of drug development has always aimed and is constantly working on developing disease modifying drugs, but these drugs will only succeed when given in the early disease stages. Thus, developing efficient diagnostic tools is of vital importance. Various nanomaterials such as liposomes; dendrimers; polymeric nanoparticles; coordination polymers; inorganic nanoparticles such as silica, manganese oxide, zinc oxide, iron oxide, super paramagnetic iron oxides; quantum dots, silver nanoparticles, gold nanoparticles, and carbon based nanostructures (carbon nanotubes, graphene oxide, nanofibres, nanodiamonds, carbon dots); Up-conversion nanoparticles; 2D nanomaterials; and radioactive nanoprobes have been used in constructing and improving efficiency of nano-sensors for AD biosensing at an early stage of diagnosis. |
| Databáze: | OpenAIRE |
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