Expression of several cytokines in prostate cancer: Correlation with clinical variables of patients. Relationship with biochemical progression of the malignance
| Autor: | Norelia Torrealba, Benito Fraile, Pilar Martínez-Onsurbe, Gonzalo Rodríguez-Berriguete, Manuel Guil-Cid, Ricardo Paniagua, Mar Royuela, Gabriel Olmedilla |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology Prognostic variable medicine.medical_specialty Pathology Multivariate analysis medicine.medical_treatment Immunology Biochemistry 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine Biomarkers Tumor Humans Immunology and Allergy Medicine Stage (cooking) Molecular Biology Lymph node Pathological Aged business.industry Prostatectomy Prostatic Neoplasms Hematology Middle Aged Hyperplasia Prognosis medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cytokines business |
| Zdroj: | Cytokine. 89:105-115 |
| ISSN: | 1043-4666 |
| Popis: | Background This work is focused on finding new markers that complement or diagnoses currently used towards improving knowledge histological and statistical aspects that allow us to predict the local stage carcinomas and to identify and understand all the factors related to the progression of this disease. Materials and methods Prostates were obtained from: normal prostates from 20 men, diagnosis of BPH (Benign Prostatic Hyperplasia) from 35 men and prostate cancer from 86 men. We studied the behavior of cytokines that have been implicated in inflammatory processes: TNF-alfa, IL-6, IL-1, EGF and TGF-B. Expression of these cytokines and its receptors was analyzed by immunohistochemistry. Spearman’s test, Kaplan-Meier curves, univariate and multivariate Cox proportional hazard regression analyses were performed. Results Spearman’s analysis showed that there was at least one correlation between TGFB-B, IL-6, gp-130, IL-1B, IL-1R, IL-1RII and clinic pathological feature (preoperative serum PSA, clinical t stage, pathological t stage, positive surgical margins, biochemical progression, survival). Immunostaining score was correlated with some of the clinicopathological feature. In Cox multivariate analysis between the prognostic variables (pathological T stage, Gleason score and lymph node) and immunohistochemical parameters (TGF-B, IL-1a, intensity TGFBRI and intensity TGFBRII) only the expression of IL-1a was retained as independent predictors of biochemical progression after radical prostatectomy. Conclusions Our results suggest a role for prostatic expression of TGF-B, IL-1a, TGFBRI and TGFBRII as prognostic markers for prostate cancer. The rational combination of novel agents directed toward the inactivation of TGF-B, IL-1a, TGFBRI and TGFBRII could disrupt complementary tumor cell proliferation pathways. |
| Databáze: | OpenAIRE |
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