Cortical thickness in fetal alcohol syndrome and attention deficit disorder
| Autor: | Sonia López Arribas, Juan Manuel García-Segura, Nuria Muñoz Jareño, Daniel Martín Fernández-Mayoralas, Alberto Fernández-Jaén, Diana Quiñones Tapia, Beatriz Calleja-Pérez |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Brain development Adolescent Fetal alcohol syndrome Alcohol Neuroimaging Statistics Nonparametric chemistry.chemical_compound Developmental Neuroscience Pregnancy Internal medicine medicine Attention deficit hyperactivity disorder Humans In patient Psychiatry Child Cerebral Cortex Attention deficit disorder medicine.disease Right frontal lobe Endocrinology Neurology chemistry Attention Deficit Disorder with Hyperactivity Fetal Alcohol Spectrum Disorders Pediatrics Perinatology and Child Health Female Neurology (clinical) Psychology |
| Zdroj: | Pediatric neurology. 45(6) |
| ISSN: | 1873-5150 |
| Popis: | Fetal alcohol syndrome represents the classic and most severe manifestation of epigenetic changes induced by exposure to alcohol during pregnancy. Often these patients develop attention deficit hyperactivity disorder. We analyzed cortical thickness in 20 children and adolescents with fetal alcohol syndrome and attention deficit hyperactivity disorder (group 1), in 20 patients without fetal alcohol syndrome (group 2), and in 20 control cases. The first group revealed total cortical thickness significantly superior to those of the other two groups. In per-lobe analyses of cortical thickness, group 1 demonstrated greater cortical thickness in the frontal, occipital, and right temporal and left frontal lobes compared with the second group, and in both temporal lobes and the right frontal lobe compared with the control group. This study demonstrated greater cortical thickness in patients with attention deficit hyperactivity disorder and heavy prenatal exposure to alcohol, probably as an expression of immature or abnormal brain development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect