Impact of the oxidative and enzymatic metals in degenerated intervertebral disc disease
| Autor: | Anetta Zioła-Frankowska, Jacek Kaczmarczyk, Łukasz Kubaszewski, Janusz Adamek, Mikołaj Dąbrowski, Marcin Frankowski |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Intervertebral Disc Degeneration Oxidative phosphorylation Degeneration (medical) medicine.disease_cause Mass Spectrometry Degenerative disc disease Young Adult medicine Humans Intervertebral Disc Waste Management and Disposal Ecology Evolution Behavior and Systematics Aged Chemistry Public Health Environmental and Occupational Health Intervertebral disc Middle Aged medicine.disease Trace Elements Oxidative Stress Degenerated intervertebral disc medicine.anatomical_structure Metals Biophysics Female Negative correlation Intervertebral Disc Displacement Oxidative stress |
| Zdroj: | Annals of Agricultural and Environmental Medicine. 28:491-501 |
| ISSN: | 1898-2263 1232-1966 |
| DOI: | 10.26444/aaem/126178 |
| Popis: | INTRODUCTION The degenerative process of the intervertebral disc is a heterogeneous process that may exist in two forms, and involves dominant degenerative changes within the nucleus pulposus and the annulus fibrosus. In degenerative disc disease, the oxidative stress factor can play an important role. OBJECTIVE The aim of research was to present a new approach to understanding the role of the analyzed elements in the process of degeneration of the intervertebral disc. MATERIAL AND METHODS Selected elements from oxidative groups (Fe, Zn, Mo, As, Se), associated with enzymatic processes (Fe, Mo, Se, Zn, Ag, As, Bi), metals (Fe, Zn, Mo, Li) and metalloids (As, Bi) and their content was analyzed depending on the changes in the radiological images of the intervertebral disc. Elemental content analysis was performed by Inductively Coupled Plasma Mass Spectrometry analytical technique. RESULTS The similarity between Fe and Se has been demonstrated during different stages of the analysis of groups of patients with degenerative disc disease. There was a negative correlation between Li and degenerative disc disease. The results also suggest that Fe and Ag are involved in degenerative changes within the intervertebral disc. A potential relationship between As/Bi and Fe/Mo in the degeneration of the intervertebral disc was demonstrated. CONCLUSIONS Only some of the correlations can be explained by the metabolism of morphological elements of the intervertebral disc. The relationships indicate new directions for further studies on the degeneration process of the intervertebral disc. The presented study may reflect metabolic changes in the intervertebral disc and adjacent structures in response to the progressive degenerative process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|