| Autor: |
Raphael Allgaier, Christina Strack, Stefan Wallner, Ute Hubauer, Ekrem Uecer, Petra Lehn, Andreas Keyser, Andreas Luchner, Lars Maier, Carsten Jungbauer |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Biomarkers in medicine. 16(4) |
| ISSN: |
1752-0371 |
| Popis: |
Aim: NAG and KIM-1 as markers of tubular damage are suggested as potential biomarkers for the cardiorenal syndrome. The aim of the study was to assess the prognostic capability of NAG and KIM-1 regarding progression of chronic kidney disease (CKD) in patients with implantable cardioverter defibrillator (ICD). Materials & methods: We included 313 patients with an ICD and collected plasma and urine samples. Follow-up was performed after 51 months (interquartile range [IQR]: 25–55). The outcome of interest was continuous CKD progression defined as persistent decline in estimated glomerular filtration rate category accompanied by a ≥25% drop of baseline estimated glomerular filtration rate. Results: An average of four (IQR: 2–6) follow-up values of serum creatinine per patient were obtained. During follow-up 29 patients (9%) developed a continuous CKD progression. NAG was shown as independent predictor for continuous CKD progression (p = 0.01), opposite to KIM-1 (p = n.s.). Conclusion: NAG was shown as predictor for a progressive and real deterioration of kidney function in patients with ICD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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