Evidence for disruption of normal circadian cortisol rhythm in women with obesity

Autor: Andrew P. Bradford, Amanda A. Allshouse, Justin Chosich, Alex J. Polotsky, Nanette Santoro, Lauren W. Roth, Zain A. Al-Safi
Rok vydání: 2017
Předmět:
Zdroj: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 34(4)
ISSN: 1473-0766
Popis: Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis may play a role in the pathogenesis of comorbidities encountered in obesity, including the relative hypogonadotropic hypogonadism that we and others have observed. We sought to examine serum cortisol profiles throughout the day and evening in a sample of normal weight women and women with obesity. In this cross-sectional study, regularly cycling obese (n = 12) and normal weight (n = 10) women were recruited. Mean serum cortisol was measured by frequent blood sampling for 16 h (8am-midnight) in the luteal phase of the menstrual cycle. Women with obesity had significantly higher overall cortisol levels when compared to normal weight women (6.2 [4.3, 6.6] vs. 4.7 [3.7, 5.5] ug/dl, p = .04). Over the two-hour postprandial period, obese women displayed an almost two-fold greater (7.2 [6.5, 8.6] ug/dl) rise in cortisol than normal weight controls (4.4 [3.7, 6.2] ug/dl, p
Databáze: OpenAIRE