Evidence for disruption of normal circadian cortisol rhythm in women with obesity
Autor: | Andrew P. Bradford, Amanda A. Allshouse, Justin Chosich, Alex J. Polotsky, Nanette Santoro, Lauren W. Roth, Zain A. Al-Safi |
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Rok vydání: | 2017 |
Předmět: |
Adult
medicine.medical_specialty Hypothalamo-Hypophyseal System Evening Hydrocortisone Endocrinology Diabetes and Metabolism media_common.quotation_subject Pituitary-Adrenal System 030209 endocrinology & metabolism Luteal phase Article 03 medical and health sciences 0302 clinical medicine Endocrinology Hypogonadotropic hypogonadism Internal medicine medicine Humans 030212 general & internal medicine Circadian rhythm Obesity Menstrual cycle media_common business.industry Obstetrics and Gynecology Luteinizing Hormone medicine.disease Circadian Rhythm Postprandial Cross-Sectional Studies Female business medicine.drug Blood sampling |
Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 34(4) |
ISSN: | 1473-0766 |
Popis: | Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis may play a role in the pathogenesis of comorbidities encountered in obesity, including the relative hypogonadotropic hypogonadism that we and others have observed. We sought to examine serum cortisol profiles throughout the day and evening in a sample of normal weight women and women with obesity. In this cross-sectional study, regularly cycling obese (n = 12) and normal weight (n = 10) women were recruited. Mean serum cortisol was measured by frequent blood sampling for 16 h (8am-midnight) in the luteal phase of the menstrual cycle. Women with obesity had significantly higher overall cortisol levels when compared to normal weight women (6.2 [4.3, 6.6] vs. 4.7 [3.7, 5.5] ug/dl, p = .04). Over the two-hour postprandial period, obese women displayed an almost two-fold greater (7.2 [6.5, 8.6] ug/dl) rise in cortisol than normal weight controls (4.4 [3.7, 6.2] ug/dl, p |
Databáze: | OpenAIRE |
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