Cerebral HSV-1 Vasculitis as a Fatal Complication of Immunosuppression in Non-Hodgkin´s Lymphoma: A Case Report and Review of the Literature
| Autor: | Francesco Brigo, Johann Sellner, Luca Carnicelli, Raffaele Nardone, Larissa Hauer, Slaven Pikija |
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| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty opportunistic infection viral encephalitis lcsh:Medicine Case Report splenic marginal cell lymphoma immune system diseases hemic and lymphatic diseases immunosuppression medicine Immunology and Allergy non-hodgkin´s lymphoma Splenic marginal zone lymphoma Molecular Biology General Immunology and Microbiology business.industry Viral encephalitis lcsh:R medicine.disease Dermatology Lymphoma Non-Hodgkin's lymphoma ddc Infectious Diseases cerebral vasculitis Vasculitis business Encephalitis Febrile neutropenia Cerebral vasculitis |
| Zdroj: | Pathogens, Vol 9, Iss 3, p 193 (2020) Pathogens |
| Popis: | Patients with lymphoma are predisposed to infection because of the immunocompromised state related to the disease itself and as a consequence of chemo-/radiotherapy. Here, we report a case of Herpes-simplex virus encephalitis (HSE) in an immunosuppressed patient with splenic marginal zone lymphoma (SMZL), a rare indolent variant of non-Hodgkin´s lymphoma (NHL). The course was complicated febrile neutropenia and HSV-1-related cerebral vasculitis causing progressive ischemic stroke. This case illustrates the expanding spectrum of atypical clinical and radiological manifestations of HSE in patients treated with myelotoxic drugs. Moreover, we summarize the few central nervous system manifestations of SMZL reported in the literature and discuss distinct causes of neurological deterioration in patients with NHL. |
| Databáze: | OpenAIRE |
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