Detection of Drug Resistance Mutations in the Reverse Transcriptase Gene of HIV-1-Infected North Indian Population Failing First-Line Antiretroviral Therapy 'A Follow-Up Cohort Study'

Autor:	Srikanth Tripathy, Shripad A. Patil, Partha Sarathi Mohanty, Tej Pal Singh, Avi Kumar Bansal, Sheetal Tomar, Srikanta Jena, Luke Elizabeth Hanna, Ramesh Karunaianantham, Rekha Tandon, Sushanta Kumar Barik, Sathyamoorthy Pattabiraman, Keshar Kunja Mohanty
Rok vydání:	2021
Předmět:	medicine.medical_specialty Efavirenz Nevirapine Anti-HIV Agents Immunology India HIV Infections Drug resistance chemistry.chemical_compound Acquired immunodeficiency syndrome (AIDS) Abacavir Antiretroviral Therapy Highly Active Virology Internal medicine Drug Resistance Viral Humans Medicine Treatment Failure business.industry Lamivudine Viral Load Resistance mutation medicine.disease HIV Reverse Transcriptase Infectious Diseases chemistry Mutation HIV-1 business Viral load Follow-Up Studies medicine.drug
Zdroj:	AIDS Research and Human Retroviruses. 37:796-805
ISSN:	1931-8405 0889-2229
Popis:	We aim to characterize the drug resistance mutations in reverse transcriptase gene of HIV-1 subtype C-infected North Indian population in those who are failing first-line antiretroviral therapy (ART) and if these mutations are associated with mortality. We also attempted the assessment of switch over to second-line antiretroviral therapy in these patients. Based on the immunological marker CD4 count (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5fa939e8ca0292bc6d7fce37fc3e8b https://doi.org/10.1089/aid.2020.0132 Zobrazit plný text záznamu