Circulating microRNA-155 is associated with insulin resistance in chronic hepatitis C patients
| Autor: | Zeinab A. Hassan, Zeinab M. Hefny, Nourhan M. El Samaloty, Dalia H. A. Abdelaziz |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male Type 2 diabetes Virus Pathogenesis 03 medical and health sciences 0302 clinical medicine Insulin resistance Chronic hepatitis microRNA medicine Homeostasis Humans Glycated Hemoglobin business.industry Gastroenterology Hepatitis C Fasting Hepatitis C Chronic Middle Aged medicine.disease Circulating MicroRNA MicroRNAs Diabetes Mellitus Type 2 ROC Curve 030220 oncology & carcinogenesis Case-Control Studies Immunology 030211 gastroenterology & hepatology Female Insulin Resistance business Biomarkers |
| Zdroj: | Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 20(1) |
| ISSN: | 2090-2387 |
| Popis: | Background and study aim Hepatitis C represents a potential public health problem worldwide. Insulin resistance (IR) and type 2 diabetes (T2D) are among the serious metabolic complications for chronic hepatitis C virus (HCV) infection. MicroRNAs (miRNAs) are a group of small non-coding RNAs which are implicated in the modulation of almost all biological processes . The objective of this study was to investigate the levels of both miR-155 and miR-34a in sera of chronic HCV patients with or without T2D. Patients and methods In this study, we investigated the expression of both miR-155 and miR-34a in 80 subjects (20 HCV, 19 HCV/T2D, 21 T2D and 19 healthy controls), using quantitative real-time PCR. Results Our results revealed significantly higher levels of both miR-155 and miR-34a in chronic HCV patients compared to healthy control subjects. However, only circulating miR-155 levels showed significant decline in diabetic HCV patients compared to non-diabetic HCV group. Intriguingly, the circulating levels of miR-155 were inversely correlated with HOMA-IR, fasting blood glucose and HbA1c levels. Conclusion Our findings indicate that the insulin resistance and T2D in HCV are strongly related to miR-155. This may suggest a role for miR-155 in the pathogenesis of IR caused by HCV. However, further large-scale studies are required to confirm our findings. |
| Databáze: | OpenAIRE |
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