Red ginseng polysaccharide alleviates cytotoxicity and promotes anti-inflammatory activity of ginsenosides
| Autor: | Yu， Kwang-won, Sung Min Cho, Hyung Joo Suh, Woo Jung Kim, Hoon Sik Kim, Ki-Bae Hong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
chemistry.chemical_classification
Nutrition. Foods and food supply Chemistry medicine.drug_class ginsenoside Pharmacology Korean Red ginseng Polysaccharide Anti-inflammatory chemistry.chemical_compound Ginseng Ginsenoside polysaccharide medicine T1-995 Cytotoxic T cell cytotoxicity TX341-641 Cytotoxicity anti-inflammatory activity Technology (General) Food Science Biotechnology |
| Zdroj: | Food Science and Technology v.42 2022 Food Science and Technology (Campinas) Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA Food Science and Technology, Issue: ahead, Published: 22 FEB 2021 Food Science and Technology (2021) Food Science and Technology, Volume: 42, Article number: e52220, Published: 22 FEB 2021 |
| Popis: | Although Ginsenosides are a major physiological component of red ginseng (RG), some isolated ginsenosides are known to have cytotoxic activity. This study was intended to reduce cytotoxicity and promote anti-inflammatory activity of ginsenosides by mixing the crude ginsenosides (RG-CG) and polysaccharides (RG-CP). RG-CG-CM, fractionated from RG-CG, not only had higher anti-inflammatory activity than that of RG-CG at 100 μg/mL, but also showed increased cytotoxicity, while RG-CP-4P and RG-CP-8P, fractionated from RG-CP, showed no anti-inflammatory activity and cytotoxicity. To reduce the cytotoxicity without affecting the high anti-inflammatory activity of RG-CG-CM, RG-CG-CM and RG-CP-4P were mixed in a ratio of 2:8. The anti-inflammatory activity was significantly increased at a concentration of 75 μg/mL, while no cytotoxicity was observed. A combination of RG-CP and RG-CG effectively reduced the cytotoxicity and enhanced the anti-inflammatory activity of RG-CG, specifically RG-CG-CM fraction, providing scope for its industrial application. |
| Databáze: | OpenAIRE |
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