Therapeutic effect of autologous concentrated growth factor on lower-extremity chronic refractory wounds: A case report
| Autor: | Shi Xu, Liu Yang, Chang-Neng Ke, Po Liu, Wei-Shan Li, Yue-Ming Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chronic refractory wounds
Lower extremity medicine.medical_specialty integumentary system business.industry Growth factor medicine.medical_treatment Therapeutic effect Wound healing General Medicine Surgery 03 medical and health sciences 0302 clinical medicine Refractory Concentrated growth factors 030220 oncology & carcinogenesis Case report medicine 030211 gastroenterology & hepatology business Ulcer |
| Zdroj: | World Journal of Clinical Cases |
| ISSN: | 2307-8960 |
| DOI: | 10.12998/wjcc.v9.i18.4797 |
| Popis: | BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons. Because of poor blood supply, less tissue coverage, and easy exposure, the lower leg is a common site for chronic refractory wounds. The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs. Concentrated growth factor (CGF) is a novel blood extract that contains various growth factors, platelets, and fibrins to promote wound healing process. However, there has been little research reported on the treatment of lower extremity wounds with CGF. CASE SUMMARY A 37-year-old man, without any past medical history, presented an ulcerated chronic wound on his right lower leg. The skin defect exhibited clear boundaries, with a size of 2.0 cm × 3.5 cm. The depth of wound was up to the layer of deep fascia. Staphylococcus aureus was detected by bacterial culture. The final diagnosis was right lower extremity ulcers with infection. Cefathiamidine, silver sulfadiazine, and mupirocin cream were applied to control the infection. CGF gel was prepared from the patient’s blood sample, and was used to cover the wound after thorough debridement. The skin wound was successfully healed after three times of CGF treatment. CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lower-extremity chronic refractory wounds. |
| Databáze: | OpenAIRE |
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