fosM , a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota
| Autor: | Sophie Alexandra Baron, Seydina M. Diene, Sami Khabthani, Jean-Marc Rolain, Mouna Hamel, Vicky Merhej |
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| Přispěvatelé: | Microbes évolution phylogénie et infections (MEPHI), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
bacillithiol transferase
medicine.drug_class In silico Antibiotics Fosfomycin Biology medicine.disease_cause Genome fosfomycin resistance Microbiology 03 medical and health sciences Minimum inhibitory concentration [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Mechanisms of Resistance [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases medicine Pharmacology (medical) [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology human microbiota Gene Escherichia coli ComputingMilieux_MISCELLANEOUS 030304 developmental biology FosM Pharmacology 0303 health sciences [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases 030306 microbiology Human microbiome biochemical phenomena metabolism and nutrition [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology phylogenetics Infectious Diseases [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology genomes medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2021, 65 (2), ⟨10.1128/AAC.01712-20⟩ Antimicrobial Agents and Chemotherapy, 2021, 65 (2), ⟨10.1128/AAC.01712-20⟩ Antimicrob Agents Chemother Antimicrobial Agents and Chemotherapy, 2021, 65 (2), pp.e01712-20. ⟨10.1028/aac.01712-20⟩ Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2021, 65 (2), pp.e01712-20. ⟨10.1028/aac.01712-20⟩ |
| ISSN: | 0066-4804 1098-6596 |
| Popis: | International audience; ABSTRACT Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined in vitro/in silico approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Escherichia coli strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named fosM . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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