Rotated nursing environment with underfeeding: A form of early-life adversity with sex- and age-dependent effects on coping behavior and hippocampal neurogenesis
| Autor: | Joanna Medina, Rose M. De Guzman, Joanna L. Workman, Angela I. Saulsbery |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Doublecortin Protein Neurogenesis Hippocampus Experimental and Cognitive Psychology Hippocampal formation Open field Rats Sprague-Dawley 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Nursing Adverse Childhood Experiences Adaptation Psychological Medicine Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology biology business.industry Dentate gyrus 05 social sciences Sham surgery Doublecortin Rats biology.protein Female business 030217 neurology & neurosurgery Behavioural despair test |
| Zdroj: | Physiologybehavior. 225 |
| ISSN: | 1873-507X |
| Popis: | We investigated how a unique form of early-life adversity (ELA), caused by rotated nursing environment to induce underfeeding, alters anxiety-like and stress-coping behaviors in male and female Sprague Dawley rats in adolescence and adulthood. Adult female rats underwent either thelectomy (thel; surgical removal of teats), sham surgery, or no surgery (control) before mating. Following parturition, litters were rotated between sham and thel rats every 12 h to generate a group of rats that experienced ELA (rotated housing, rotated mother, and 50% food restriction) from postnatal day 0 to 26. Control litters remained with their natal, nursing dams. Regardless of age and sex, ELA reduced activity in the periphery of the open field. ELA increased immobility in the forced swim test, particularly in adults. We used doublecortin immunohistochemistry to identify immature neurons in the hippocampus. ELA increased the number and density of immature neurons in the dentate gyrus of adolescent males (but not females) and reduced the density of immature neurons in adult males (but not females). This research indicates that a unique form of ELA alters stress-related passive coping and hippocampal neurogenesis in an age- and sex-dependent manner. |
| Databáze: | OpenAIRE |
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