Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trial
| Autor: | D J Girling |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Severity of Illness Index law.invention Postoperative Complications Randomized controlled trial law Antineoplastic Combined Chemotherapy Protocols Preoperative Care medicine Humans Infusions Intravenous Aged Aged 80 and over Intention-to-treat analysis Performance status business.industry Hazard ratio Cancer General Medicine Middle Aged Esophageal cancer medicine.disease Survival Analysis Surgery Radiation therapy Fluorouracil Female Cisplatin Deglutition Disorders business medicine.drug |
| Zdroj: | The Lancet. 359:1727-1733 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(02)08651-8 |
| Popis: | Summary Background The outlook for patients with oesophageal cancer undergoing surgical resection with curative intent is poor. We aimed to assess the effects of preoperative chemotherapy on survival, dysphagia, and performance status in this group of patients. Methods 802 previously untreated patients with resectable oesophageal cancer of any cell type were randomly allocated either two 4-day cycles, 3 weeks apart, of cisplatin 80 mg/m 2 by infusion over 4 h plus fluorouracil 1000 mg/m 2 daily by continuous infusion for 4 days followed by surgical resection (CS group, n=400), or resection alone (S group, 402). Clinicians could choose to give preoperative radiotherapy to all their patients irrespective of randomisation. Primary outcome measure was survival time. Analysis was by intention to treat. Findings No patients dropped out of the study. Resection was microscopically complete in 233 (60%) of 390 assessable CS patients and 215 (54%) of 397 S patients (p |
| Databáze: | OpenAIRE |
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