Identification of 11 Different HPV Subtypes in Adult Patients With Recurrent Respiratory Papillomatosis
Autor: | Robert W. Bastian, Rebecca C. Hoesli, Brent E. Richardson, Melissa L Wingo |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male Biopsy Adult population Alphapapillomavirus Polymerase Chain Reaction 03 medical and health sciences 0302 clinical medicine Humans Medicine Respiratory system Human papillomavirus 030223 otorhinolaryngology Respiratory Tract Infections Retrospective Studies Adult patients business.industry Papillomavirus Infections Otorhinolaryngology 030220 oncology & carcinogenesis DNA Viral Immunology Female Surgery Identification (biology) Recurrent Respiratory Papillomatosis business |
Zdroj: | Otolaryngology–Head and Neck Surgery. 163:785-790 |
ISSN: | 1097-6817 0194-5998 |
Popis: | To define the human papillomavirus (HPV) subtypes seen in a large adult population with traditionally defined recurrent respiratory papillomatosis.Retrospective review.Tertiary care laryngology practice.All patients had a firm diagnosis of recurrent respiratory papillomatosis defined by (1) visually obvious papillomas, (2) recurrence requiring multiple surgeries, and (3) pathology diagnosis of "papilloma." Each patient had also undergone HPV subtyping. Age, sex, presence of malignancy, and HPV subtypes were tabulated and correlated with long-term patient outcomes.A total of 184 patients were identified who fulfilled the above criteria. In total, 87.0% (160) had a low risk subtype; 9.2% had an alternative subtype. These consisted of subtypes 16, 18, 31, 44, 45, 55, and 70. Four patients (2.2%) had combinations of subtypes, with 1 patient with HPV 11 and 16, 1 patient with HPV 11 and 76, 1 patient with 11 and 84, and 1 patient with 18 and 45. Finally, 3.8% of patients were HPV negative, despite fulfilling all 3 criteria listed above.In the patient population above, almost 10% of patients had an HPV subtype other than 6 and 11. This suggests that traditionally defined recurrent respiratory papillomatosis (RRP) can be caused by HPV subtypes other than 6 and/or 11. In addition, the clinical course of persons with this definition of RRP appears to vary by subtype, and this information may offer the ability to nuance follow-up instructions, reducing in particular the burden placed upon patients who have RRP caused by subtypes 6 and 11. |
Databáze: | OpenAIRE |
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