18F-Fluoride PET/CT Allows Detection of Hyperostosis and Osseous Involvement in Meningioma
| Autor: | Ukihide Tateishi, Kazuya Shizukuishi, Nobutaka Kawahara, Ayako Shishikura, Hidetoshi Murata, Kensuke Tateishi, Tomio Inoue |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Fluorine Radioisotopes Hyperostosis medicine.medical_specialty Bone Neoplasms Multimodal Imaging Meningioma Fluorides Meningeal Neoplasms Humans Medicine Radiology Nuclear Medicine and imaging Pathological Aged PET-CT medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Primary tumor Positron emission tomography Positron-Emission Tomography Lean body mass Female Radiology Tomography X-Ray Computed business Nuclear medicine 18f fluoride |
| Zdroj: | Clinical Nuclear Medicine. 38:e125-e131 |
| ISSN: | 0363-9762 |
| DOI: | 10.1097/rlu.0b013e318279fd79 |
| Popis: | Purpose The present study was conducted to assess the diagnostic performance of (18)F-fluoride PET/CT in evaluating hyperostosis and osseous involvement in patients with meningioma. Patients and methods Thirty-four patients with meningioma (mean age, 61 years) underwent (18)F-fluoride PET/CT before surgery. In 24 patients (71%), (18)F-FDG PET/CT was also given before surgery, and the results were compared. The images were reviewed by 2 board-certified nuclear medicine specialists who were unaware of any clinical information and a consensus was reached. Uptake patterns and measurements of tracers were compared with pathological findings from resected specimens, with hyperostosis and osseous involvement as the reference standard. Results There were 27 grade I tumors (79%) and 7 grade II tumors (21%). The primary tumor focus was identified in each patient using both (18)`F-fluoride PET/CT and (18)F-FDG PET/CT, but there were no significant correlations in the degree of uptake between the 2 tracers. The SUV(max), SUV(max) corrected for lean body mass (SUL(max)), and tumor metabolic volume (TMV) for (18)F-fluoride and (18)F-FDG were greater in grade II tumors than in grade I tumors. Hyperostosis and osseous involvement was identified in 12 tumors (38%). The SUV(max), SUL(max), and TMV of tumors visualized with (18)F-fluoride PET/CT were greater in tumors with hyperostosis and osseous involvement than in those without (P = 0.005, P = 0.003, and P = 0.006, respectively). In contrast, the SUV(max), SUL(max), and TMV of tumors visualized with (18)F-FDG PET/CT were similar regardless of hyperostosis or osseous involvement. Conclusions (18)F-fluoride PET/CT may improve detection of hyperostosis and osseous involvement in patients with meningioma. |
| Databáze: | OpenAIRE |
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