Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population
Autor: | Awatif N. Al-Nafaie, Sayed AbdulAzeez, Ali S Al-Sahwan, Sadananda Acharya, Abdulmohsen H. Al-Elq, Maha S Al-Shammari, Amein K. Al-Ali, Fadi N Busaleh, Rhaya Al-Ali, Mansour S Al-Enazi, Nader Al-Balawi, Jesu Francis Borgio, Ali A Al-Muraikhi |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:QH426-470 endocrine system diseases genetic association Haploview Population 030209 endocrinology & metabolism Single-nucleotide polymorphism Type 2 diabetes Biology Saudi population Gastroenterology 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine Genetics medicine SNP T2D education Molecular Biology Genetic association education.field_of_study KCNQ1 Haplotype medicine.disease CVD lcsh:Genetics 030104 developmental biology Human and Medical Genetics |
Zdroj: | Genetics and Molecular Biology v.40 n.3 2017 Genetics and Molecular Biology Sociedade Brasileira de Genética (SBG) instacron:SBG Genetics and Molecular Biology, Volume: 40, Issue: 3, Pages: 586-590, Published: 31 AUG 2017 Genetics and Molecular Biology, Vol 40, Iss 3, Pp 586-590 (2017) |
Popis: | Genome-wide association studies have identified several loci associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes (T2D). Polymorphisms within the KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) gene are consistently associated with T2D in a number of populations. The current study was undertaken to evaluate the association of 3 polymorphisms of KCNQ1 (rs2237892, rs151290 and rs2237895) with T2D and/or CVD. Patients diagnosed with either T2D (320 patients), CVD (250 patients) or both (60 patients) and 516 healthy controls were genotyped by TaqMan assay run on a real time PCR thermocycler. A statistically significant association was found for SNPs rs151290 (OR = 1.76; 95%CI = 1.02-3.05; p = 0.0435) and rs2237895 (OR = 2.49; 95%CI = 1.72-3.61; p < 0.0001) with CVD. SNP rs151290 (OR = 7.43; 95%CI = 1.00-55.22; p = 0.0499) showed a strong association in patients with both T2D and CVD. None of the SNPs showed any significant association with T2D. Haploview analysis showed that the ACC (rs151290, rs2237892 and rs2237895) haplotype is the most significant risk allele combination for CVD, while CCA is the most significant risk haplotype for co-morbidity with T2D. KCNQ1 polymorphism at SNPs rs151290 and rs2237895 is strongly associated with CVD in this population, but presented no association with T2D. |
Databáze: | OpenAIRE |
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