Prognostic and predicted significance of Ubqln2 in patients with hepatocellular carcinoma

Autor: Xiao-Yu Liu, Hong-Qiang Yu, Geng Chen, Lai Jiejuan, Ling Shuai, Haisu Dai, Chuan-Ming Xie, Ping Bie, Lei Fang, Leida Zhang, Yuan-Deng Luo, Yujun Zhang, Yan Jiang, Deng Huang
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Oncology
Cancer Research
Autophagy-Related Proteins
UBQLN2
0302 clinical medicine
Medicine
CTNNB1
HCC
Original Research
Cause of death
biology
Liver Neoplasms
Ubqln2
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Gene Expression Regulation
Neoplastic
Survival Rate
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Immunohistochemistry
Female
medicine.medical_specialty
Carcinoma
Hepatocellular
overall survival
lcsh:RC254-282
nomogram
03 medical and health sciences
Internal medicine
Biomarkers
Tumor
Overall survival
Humans
Radiology
Nuclear Medicine and imaging
Gene
Adaptor Proteins
Signal Transducing
Retrospective Studies
business.industry
Proportional hazards model
Clinical Cancer Research
Nomogram
medicine.disease
digestive system diseases
Nomograms
030104 developmental biology
biology.protein
business
Follow-Up Studies
Zdroj: Cancer Medicine
Cancer Medicine, Vol 9, Iss 12, Pp 4083-4094 (2020)
ISSN: 2045-7634
Popis: Purpose Hepatocellular carcinoma (HCC) is a common malignant cancer and the third leading cause of death worldwide. The molecular mechanism of HCC remains unclear. Recent studies have demonstrated that the ubiquitin‐proteasome system (UPS) is associated with HCC. Ubqln2, a member of the UPS, is abnormally expressed in HCC. However, whether Ubqln2 is associated with HCC prognosis remains unknown. Patients and Methods We analyzed the associations between overall survival and various risk factors in 355 HCC tissue samples obtained from the Cancer Genomic Atlas (TCGA) database at the mRNA level and in 166 HCC tissue samples from Southwest Hospital at the protein level. qRCR was used to determinate Ubqln2 expression in cancer and noncancerous tissues. The association between Ubqln2 and Ki‐67 was analyzed by immunohistochemistry. The association between Ubqln2 expression and survival was analyzed using Kaplan‐Meier curve and Cox proportional hazards models. A nomogram was used to predict the impact of Ubqln2 on prognosis. Mutated genes were analyzed to determine the potential mechanism. Results Ubqln2 highly expressed in HCC tissues. The Ubqln2 mRNA level had significant relations with UICC tumor stage (P = .022), UICC stage (P = .034) and resection potential (P = .017). Concordantly, the Ubqln2 protein was closely associated with tumor size (P = .005), UICC stage (P = .012), and recurrence (P = .009). Ubqln2 was highly expressed in HCC and positively associated with poor survival. The nomogram precisely predicted the prognosis of HCC patients with high or low Ubqln2 expression. A genomic waterfall plot suggested that Ubqln2 expression was closely associated with mutated CTNNB1. Conclusion Our findings reveal that Ubqln2, an independent risk factor for HCC, is a potential prognostic marker in HCC patients. Ubqln2 expression is positively associated with mutated CTNNB1.
Ubqln2 is abnormally expressed in HCC but its role remains unknown. Here, we reported that Ubqln2, an independent risk factor for HCC, is a potential prognostic marker in HCC patients. Ubqln2 expression is positively associated with mutated CTNNB1.
Databáze: OpenAIRE
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