ABO blood type B and fucosyltransferase 2 non-secretor status as genetic risk factors for chronic pancreatitis
| Autor: | Julia Mayerle, Frank Ulrich Weiss, Claudia Schurmann, Markus M. Lerch, Alexander Teumer, Uwe Völker, Henry Völzke, Peter Simon, Georg Homuth, Jens-Peter Kuehn, Andreas Greinacher, Martin Zenker |
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| Rok vydání: | 2015 |
| Předmět: |
Fucosyltransferase
Population Single-nucleotide polymorphism ABO Blood-Group System 03 medical and health sciences 0302 clinical medicine Risk Factors Pancreatitis Chronic ABO blood group system medicine Humans SNP education Genetic testing Blood type education.field_of_study biology medicine.diagnostic_test business.industry Gastroenterology Lipase Fucosyltransferases medicine.disease 030220 oncology & carcinogenesis Immunology biology.protein Pancreatitis 030211 gastroenterology & hepatology business Genome-Wide Association Study |
| Zdroj: | Gut. 65:353-354 |
| ISSN: | 1468-3288 0017-5749 |
| DOI: | 10.1136/gutjnl-2015-309682 |
| Popis: | Sir, We thank Kirsten et al 1 for their comments on our recent study,2 in which we reported a genome-wide analysis on ∼4000 volunteers from the population-based Study of Health in Pommerania (SHIP) cohort3 with replication in 1444 blood donors. We had found a significant association between higher serum lipase activities and three single nucleotide polymorphisms (SNP) as well as the fucosyltransferase-2 (FUT2) non-secretor status (homozygosity for the FUT2 p.W134X mutation) and the ABO blood type B (figure 1). In more than 1000 patients with pancreatitis, we confirmed that FUT2 non-secretor status and blood type B are also disease risk factors, with a greater than twofold OR for blood type B compared with blood type O. Figure 1 Distribution of ABO blood types in blood donor subgroups with increasing mean serum lipase activity. One thousand four hundred and forty-four blood donors were stratified into subgroups (cohort size in brackets) of increasing serum … |
| Databáze: | OpenAIRE |
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