Changes in progesterone-induced-blocking-factor expression rates following mifepristone administration in termination of pregnancy at 5 to 8 weeks
| Autor: | Yves Ville, Laurent Salomon, L. Malagrida, Patrick Rozenberg, Julia Szekeres-Bartho, Yves Giudicelli |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Immunocytochemistry Administration Oral Blocking factor Pregnancy Proteins Abortion Andrology Pregnancy Oral administration Suppressor Factors Immunologic medicine Humans Lymphocytes Obstetrics business.industry Abortifacient Agents Steroidal Venous blood sample Obstetrics and Gynecology Abortion Induced Immunosuppression Mifepristone medicine.disease Pregnancy Trimester First Pediatrics Perinatology and Child Health Female business medicine.drug |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 17:353-356 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | To study changes in the expression rate of PIBF by peripheral lymphocytes in healthy pregnant women after administration of mifepristone for non-surgical termination of pregnancy at 5-8 wks of gestation.Patients requesting early social termination of pregnancy, in a 3-month period, were included. A first venous blood sample was taken before oral administration of 600 mg of mifepristone (day 0). A second venous blood sample was taken 2 days later. PIBF on lymphocytes was determined by immunocytochemistry using a PIBF-specific polyclonal antibody.Termination of pregnancy was successful and complete in all cases. In 17 out of 21 patients, the percentage of PIBF positive lymphocytes decreased after anti-progesterone administration. The percentage of PIBF-expressing lymphocytes significantly decreased from 52.8%+/-21.6% (day 0) to 39.8%+/-18.2% by day 2 (p=0.001).These data suggest a strong relationship between early termination of pregnancy induced with mifepristone and disturbances of progesterone-mediated immunosuppression. |
| Databáze: | OpenAIRE |
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