D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement
| Autor: | Ausaf A. Bari, R. C. Pierce |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Microinjections Self Administration Nucleus accumbens Nucleus Accumbens Rats Sprague-Dawley chemistry.chemical_compound Eticlopride Dopamine receptor D1 Cocaine Internal medicine Basal ganglia Salicylamides medicine Animals Receptors Dopamine D5 Receptor SCH-23390 Dose-Response Relationship Drug General Neuroscience Receptors Dopamine D1 Receptors Dopamine D4 Antagonist Receptors Dopamine D3 Benzazepines Rats Dopamine D2 Receptor Antagonists Endocrinology chemistry Dopamine receptor Food Injections Intravenous Conditioning Operant Dopamine Antagonists Psychology Reinforcement Psychology |
| Zdroj: | Neuroscience. 135(3) |
| ISSN: | 0306-4522 |
| Popis: | Cocaine self-administration experiments were designed to assess the respective roles of D1-like and D2-like dopamine receptors in the ventral forebrain in cocaine reinforcement. D1-like or D2-like dopamine receptor antagonists were microinjected into the nucleus accumbens core, nucleus accumbens shell, neostriatum or lateral septum prior to sessions in which cocaine was self-administered under a progressive ratio schedule by rats. The results indicated that administration of a D1/5 (SCH-23390) or a D2/D3/D4 (eticlopride), but not a D3 (U99194A) or D4 (L-750,667), dopamine receptor antagonist into the core and shell of the nucleus accumbens decreased the reinforcing efficacy of cocaine. However, in control experiments intra-accumbal core administration of SCH-23390 or eticlopride decreased food self-administration, whereas administration of these drugs into the accumbens shell had no effect on food reinforcement. Neither SCH-23390 nor eticlopride influenced cocaine reinforcement when administered into the neostriatum or lateral septum. Collectively, these results indicate that D1-like and D2 dopamine receptors in the nucleus accumbens shell selectively modulate the reinforcing efficacy of cocaine, whereas D1-like and D2 dopamine receptors in the accumbens core have a more general influence on reinforced behaviors. |
| Databáze: | OpenAIRE |
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