Expression of interferon-stimulated gene 20 in vascular endothelial cells
| Autor: | Nadir Mechti, Tadaatsu Imaizumi, Hirotaka Sakaki, Tomoh Matsumiya, Kosei Kubota, Hidemi Yoshida, Hiroto Kimura, Kei Satoh |
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| Přispěvatelé: | Institute of Brain Science [Hirosaki], Hirosaki University Hospital, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2008 |
| Předmět: |
Exonucleases
Morpholines Immunology 030204 cardiovascular system & hematology Microbiology Virus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine RNA interference Virology Humans Immunologic Factors LY294002 Ribonuclease Enzyme Inhibitors Cells Cultured PI3K/AKT/mTOR pathway 030304 developmental biology 0303 health sciences Innate immune system Guanosine biology Gene Expression Profiling Interferon-stimulated gene Endothelial Cells RNA Interferon-beta Molecular biology 3. Good health Poly I-C Oligodeoxyribonucleotides chemistry Chromones Exoribonucleases [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology biology.protein Interferons |
| Zdroj: | Microbiology and Immunology Microbiology and Immunology, Wiley, 2008, 52 (1), pp.30-5. ⟨10.1111/j.1348-0421.2008.00004.x⟩ |
| ISSN: | 1348-0421 0385-5600 |
| DOI: | 10.1111/j.1348-0421.2008.00004.x |
| Popis: | ISG20 is an ribonuclease specific for single-stranded RNA and considered to play a role in innate immunity against virus infections. We herein show that both poly IC, an authentic double-stranded RNA, and IFN-gamma induced ISG20 expression in cultured HUVEC. Poly IC-induced ISG20 expression was inhibited by LY294002, an inhibitor of PI3K, or by RNA interference against IFN regulatory factor three. ISG20 expression was not induced by IFN-beta, loxoribine or CpG oligonucleotide. These results suggest that ISG20 induction by poly IC may not be dependent on the IRF-3-mediated type I IFN induction pathway in HUVEC. ISG20 may be involved in innate immunity against viral infection in vascular endothelial cells. |
| Databáze: | OpenAIRE |
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