Induction of protection in murine experimental models againstTrichinella spiralis: an up-to-date review
| Autor: | Guadalupe Ortega-Pierres, A. Vaquero-Vera, Raúl Argüello-García, Rocío Fonseca-Liñán, Rosa María Bermúdez-Cruz |
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| Rok vydání: | 2015 |
| Předmět: |
Vaccines
Livestock Transmission (medicine) Trichinella spiralis Trichinella Trichinellosis Helminth genetics General Medicine Biology biology.organism_classification Virology Epitope Disease Models Animal Mice Immune system Antigen Antigens Helminth Animals Parasite hosting Animal Science and Zoology Parasitology |
| Zdroj: | Journal of Helminthology. 89:526-539 |
| ISSN: | 1475-2697 0022-149X |
| DOI: | 10.1017/s0022149x15000140 |
| Popis: | The parasitic nematodeTrichinella spiralis, an aetiological agent of the disease known as trichinellosis, infects wild and domestic animals through contaminated pig meat, which is the major source forTrichinellatransmission. Prevention of this disease by interrupting parasite transmission includes vaccine development for livestock; however, major challenges to this strategy are the complexity of theT. spiralislife cycle, diversity of stage-specific antigens, immune-evasion strategies and the modulatory effect of host responses. Different approaches have been taken to induce protective immune responses byT. spiralisimmunogens. These include the use of whole extracts or excretory–secretory antigens, as well as recombinant proteins or synthesized epitopes, using murine experimental models for trichinellosis. Here these schemes are reviewed and discussed, and new proposals envisioned to block the zoonotic transmission of this parasite. |
| Databáze: | OpenAIRE |
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