Liver adenomas and carcinomas: correlations and relationship to body weight in long-term rodent cancer bioassays
| Autor: | Michael Polkanov, Richard Wilson, George M. Gray, Igor Linkov |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Rodent 040301 veterinary sciences Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Cancer Physiology 04 agricultural and veterinary sciences Biology medicine.disease Body weight Toxicology 030226 pharmacology & pharmacy 0403 veterinary science 03 medical and health sciences 0302 clinical medicine biology.animal Argument (complex analysis) medicine Bioassay Liver cancer |
| Zdroj: | Toxicology and Industrial Health. 16:211-223 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1191/074823300678839255 |
| Popis: | The most common cancers induced in laboratory rodents are liver cancers—both adenomas and carcinomas. There has been a long argument about the relative merits of combining them or considering them separately in the interpretation of long-term bioassays for chemical carcinogenesis. In this paper, we examine various aspects of the liver adenomas and liver carcinomas as seen in the Carcinogenesis Bioassay Data System (CBDS) and Toxicology Database Management System (TDMS) databases of the National Toxicology Program (NTP). It appears that the data themselves demonstrate interesting differences between the behavior of these tumors that probably have biological origin. Specifically, we find a strong negative correlation between the appearance of adenomas and carcinomas in the same animal in both control and chemically treated groups. This relationship does not seem to result from differential survival but may be influenced by the animal's body weight. Our analysis is generally consistent with either a progression of tumors from adenoma to carcinoma or a pathologist bias (that when a carcinoma is discovered, other tumors are ignored) as possible explanations for the negative correlation. However there are some differences between male and female mice that are puzzling. While we recognize the scientific and policy reasons for combination of adenomas and carcinomas for calculations of carcinogenic potency and risk we hope that toxicologists and pathologists will be encouraged to preserve the pathological distinctiveness of the two tumor types when analyzing rodent bioassays. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|