Increased frequency of cystic fibrosis deltaF508 mutation in bronchiectasis associated with rheumatoid arthritis
| Autor: | C J Menkès, J C Kaplan, Isabelle Fajac, Daniel Dusser, D. Hubert, X Puéchal, Nadine Desmazes-Dufeu, Thierry Bienvenu |
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| Rok vydání: | 1999 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Arthritis Cystic Fibrosis Transmembrane Conductance Regulator Cystic fibrosis Gastroenterology Membrane Potentials Arthritis Rheumatoid Chlorides Immunopathology Internal medicine medicine Humans Lung volumes Sweat Aged Bronchiectasis biology business.industry Respiratory disease respiratory system Middle Aged medicine.disease Cystic fibrosis transmembrane conductance regulator Nasal Mucosa Rheumatoid arthritis Immunology Mutation biology.protein Respiratory Mechanics Female business |
| Zdroj: | The European respiratory journal. 13(6) |
| ISSN: | 0903-1936 |
| Popis: | This study investigated the clinical characteristics and the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in patients with symptomatic diffuse bronchiectasis (DB) associated with rheumatoid arthritis (RA). Twenty-six patients with both RA and DB (group RA+DB) and control groups of 29 consecutive patients with RA but no bronchiectasis (group RA) and 29 patients with symptomatic DB of unknown origin (group DB) were prospectively studied. Among the patients of the RA+DB group, four (15.4%) were heterozygous for the CFTR gene deltaF508 mutation, whereas no deltaF508 mutation was found in patients of the RA and the DB groups (both, p |
| Databáze: | OpenAIRE |
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