Evaluation of Anti-Inflammatory Activity of Aqueous Extract of Leaves of Solanum Melongena Linn. in Experimental Animals
| Autor: | Yasmeen A. Maniyar, M S Umamageswari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Melongena
Experimental Research medicine.drug_class Clinical Biochemistry lcsh:Medicine Median lethal dose Anti-inflammatory chemistry.chemical_compound ld 50 medicine Oral toxicity anti-inflammatory activity Aqueous extract Aspirin biology Traditional medicine business.industry lcsh:R fungi food and beverages General Medicine biology.organism_classification Carrageenan chemistry solanum melongena Solanum business medicine.drug |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 9, Iss 1, Pp FF01-FF03 (2015) |
| Popis: | INTRODUCTION Aqueous extract of leaves of Solanum melongena Linn was investigated for its anti-inflammatory activity. MATERIALS AND METHODS Acute oral toxicity study according to OECD425 guidelines was done to find out the LD50 of test drug. Carrageenan induced paw oedema method in Wistar Albino rats were used in this study. Aspirin in the dose of 300mg/kg was used as the standard drug and three doses of aqueous extract of leaves of Solanum melongena L. (100mg/kg, 200mg/kg, 400mg/kg b.w.) was used as the test drug. The results were measured at 1(st) h, 3(rd) h, and 5(th) h after the carrageenan injection. RESULTS In acute oral toxicity study none of the animals died at the dose of 2000mg/kg. Aqueous extract of Solanum melongena Linn leaf in the dose of 200mg/kg showed significant anti-inflammatory activity (p |
| Databáze: | OpenAIRE |
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