Nutrient intake and body composition variables in Prader-Willi syndrome--effect of growth hormone supplementation and genetic subtype
| Autor: | Suzanne B. Cassidy, Pietro Galassetti, Andria M. Pontello, O. Saetrum Opgaard |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Inheritance Patterns Nutrient intake Growth hormone Eating Endocrinology Classification of obesity Internal medicine medicine Humans In patient Single-Blind Method Child business.industry Human Growth Hormone Dietary intake Growth hormone treatment Child Preschool Pediatrics Perinatology and Child Health Body Composition Composition (visual arts) Female business Body mass index Prader-Willi Syndrome |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 20(4) |
| ISSN: | 0334-018X |
| Popis: | UNLABELLED In patients with Prader-Willi syndrome (PWS), limited information exists on the effects of growth hormone (GH) therapy, gender and genetic subtype on nutrient intake and body composition. We therefore compared GH-treated and nontreated patients, taking into account Tanner stage, gender, and genetic form. PATIENTS AND METHODS In 37 individuals with PWS (20/17 M/F; 21/16 GH+/GH-), dietary intake and body composition (BMI, DEXA) were assessed. RESULTS Older GH-treated children (Tanner stage 3-4) displayed improved body composition variables (BMI, total and percentage fat mass, truncal fat) (p < 0.05), despite dietary intake similar to non-treated patients; younger children (Tanner stage 1-2) displayed a different pattern, despite greater total caloric and fat intake (p < 0.05) with GH treatment, with only minor differences in body composition. Genetic form and gender had no intrinsic effect on nutrient intake or body composition. CONCLUSION In 37 patients with PWS, GH treatment selectively affected body composition (BMI, fat mass), and dietary fat intake based on patients' developmental status, while these variables were unaffected by gender or genetic subtype. |
| Databáze: | OpenAIRE |
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