Blood Pressure in Relation to Interactions Between Sodium Dietary Intake and Renal Handling
| Autor: | Chong-Huai Yan, Jun Zou, Fang-Fei Wei, Ji-Guang Wang, Lu Zhang, Yan Li |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Ambulatory blood pressure Lithium (medication) Sodium chemistry.chemical_element Blood Pressure Lithium Kidney Excretion Surveys and Questionnaires Internal medicine Internal Medicine medicine Humans Aged business.industry Reabsorption Dietary intake Sodium Dietary Middle Aged Blood pressure Endocrinology chemistry Hypertension Ambulatory Female business medicine.drug |
| Zdroj: | Hypertension. 62:719-725 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | There is abundant evidence that sodium intake is related to blood pressure. However, the relationship varies between individuals and is probably determined by renal sodium handling. We investigated clinic and ambulatory blood pressure in relation to interactions between sodium dietary intake and renal handling, as assessed by 24-hour urinary sodium excretion and endogenous lithium clearance, respectively. We calculated fractional excretion of lithium and fractional distal reabsorption rate of sodium, as markers of proximal and distal sodium handling, respectively. The 766 subjects included 379 men and 478 ambulatory hypertensive patients. They were never treated (n=697) or did not take antihypertensive medication for ≥2 weeks (n=69). In adjusted analyses, none of the associations of urinary sodium excretion, fractional excretion of lithium, and fractional distal reabsorption rate of sodium with clinic or ambulatory blood pressure were statistically significant ( P ≥0.09). However, there was significant ( P =0.01) interaction between urinary sodium excretion and fractional excretion of lithium in relation to nighttime diastolic blood pressure. In tertile 3 but not tertiles 1 and 2 of fractional excretion of lithium, nighttime diastolic pressure was positively associated with urinary sodium excretion ( P =0.03). However, nighttime diastolic pressure was higher in tertile 1 than tertile 3 of fractional excretion of lithium (+2.0 mm Hg; P =0.01), especially in the bottom tertile of urinary sodium excretion (+4.9 mm Hg; P |
| Databáze: | OpenAIRE |
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