Immunoglobulin D in cerebrospinal fluid
| Autor: | E.A.H. Hische, Theo A. Out, Hayo J. van der Helm, Harm K. van Walbeek |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Clinical Biochemistry
Radioimmunoassay chemical and pharmacologic phenomena Immunoglobulin E Biochemistry Immunoglobulin D Cerebrospinal fluid stomatognathic system immune system diseases hemic and lymphatic diseases Humans Medicine Guillain-Barre syndrome biology business.industry Multiple sclerosis Biochemistry (medical) hemic and immune systems General Medicine medicine.disease Immunoglobulin G Immunology biology.protein Nervous System Diseases Antibody business Meningitis |
| Zdroj: | Clinica Chimica Acta. 165:289-293 |
| ISSN: | 0009-8981 |
| Popis: | Immunoglobulin D (IgD) was measured by radioimmunoassay in paired cerebrospinal fluid and serum samples from patients with various neurological diseases. The IgD index was calculated for every patient and compared with the IgG index. An increased IgD index was found in 18 out of 41 patients suffering from multiple sclerosis and in 52 out of all 122 patients investigated. An increased IgD index did not always coincide with an increased IgG index. An increased IgD index suggests an abnormal intrathecal synthesis of this irnmunoglobulin within the central nervous system. We conclude that the determination of IgD in the cerebrospinal fluid yields additional information on immunological reactions within the central nervous system. |
| Databáze: | OpenAIRE |
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