Enhanced inflammation in subgroups of metabolic syndrome irrespective of glycaemic status
| Autor: | Hapizah Md Nawawi, Thuhairah Hasrah Abdul Rahman, Nadzimah Mohd Nasir, Hanis Saimin, Zaliha Ismail, Anis Safura Ramli, Suraya Abdul Razak, Muhamed T. Osman |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Adhesion (medicine) Inflammation medicine.disease Inflammatory biomarkers Endothelial activation Endocrinology metabolic syndrome glycaemic status inflammation endothelial activation Internal medicine Diabetes mellitus Coronary risk Medicine medicine.symptom Metabolic syndrome business Cell adhesion |
| Zdroj: | Journal of Fundamental and Applied Sciences; Vol 9, No 6S (2017): Special Issue; 331-349 |
| ISSN: | 1112-9867 |
| Popis: | The objectives of this study were toinvestigate the inflammation and endothelial activation biomarkers in subjects with metabolic syndrome (MS)subgroups irrespective of status. Subjects (n=319) were categorized into MS subgroups [diabetes mellitus (MSDM), impaired fastig glucose (MSIFG) and normoglycemia (MSNG)] and normal controls (NC). Inflammatory biomarkers (high-sensitivity C-reactive protein and interleukin-6) and endothelial activation (soluble intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin) were measured and compared between the groups. MS subjects had significant increase in all biomarkers compared to NC subjects. Glycaemic status in MS subgroups did not show any association with the quartiles of all biomarkers, except for interleukin-6. This may partially explain their increased coronary risk. Keywords : metabolic syndrome; glycaemic status; inflammation; endothelial activation |
| Databáze: | OpenAIRE |
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