Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study

Autor: Cheng-Kuo Cheng, Yi-Ting Hsieh, Ling Yeung, Chung-May Yang, Arslan Tsai, Chang-Hao Yang, San-Ni Chen, Chi-Chun Lai
Rok vydání: 2021
Předmět:
Indocyanine Green
Male
Vascular Endothelial Growth Factor A
0301 basic medicine
Oncology
medicine.medical_specialty
Visual acuity
Combination therapy
Science
Indocyanine green angiography
VEGF receptors
Taiwan
complex mixtures
Article
Macular Degeneration
03 medical and health sciences
0302 clinical medicine
Internal medicine
Prevalence
Humans
Medicine
Fluorescein Angiography
Eye manifestations
Aged
Retrospective review
Multidisciplinary
medicine.diagnostic_test
biology
business.industry
Middle Aged
Macular degeneration
medicine.disease
Fluorescein angiography
Combined Modality Therapy
Choroidal Neovascularization
Treatment Outcome
030104 developmental biology
Photochemotherapy
Vascular network
Outcomes research
030221 ophthalmology & optometry
biology.protein
Female
medicine.symptom
business
Zdroj: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
ISSN: 2045-2322
DOI: 10.1038/s41598-020-80731-1
Popis: Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (BVN) and PCV subtypes through retrospective review of indocyanine green angiography (ICGA) and fluorescein angiography images from two observational studies (RENOWNED/REAL). Of the visual outcomes for each angiographic subtype and treatment pattern investigated, BVN was identified in 56.3% of PCV patients. The proportions and features of the re-defined PCV subtypes were 43.8%, 10.4%, and 45.8% for subtype A (without distinctive features of BVN), B (with BVN but no leakage), and C (with BVN and leakage), respectively. Subtype A had better visual outcomes when compared to subtype C. This possibly resulted from a better baseline visual acuity in subtype A. Moreover, combination therapy [photodynamic therapy plus anti-vascular endothelial growth factor (VEGF)] may lead to better visual improvement than mono-anti-VEGF treatment alone. This study provides the prevalence of PCV subtypes in Taiwan and may serve as a reference for PCV treatment strategies in a real-world setting, especially for the combination therapy and patients without distinctive features of BVN.
Databáze: OpenAIRE
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