Red Cell Indices and Formulas Used in Differentiation ofβ-Thalassemia Trait from Iron Deficiency in Thai Adults

Autor:	Manoo Punyamung, Kritsanee Maneewong, Siriporn Nanta, Sanchai Wongwiwatthananukit, Sakorn Pornprasert, Jintana Yanola, Soontharee Plengsuree, Kanokwan Jaiping
Rok vydání:	2015
Předmět:	Adult Erythrocyte Indices Male medicine.medical_specialty Iron Clinical Biochemistry Mean corpuscular hemoglobin Sensitivity and Specificity Gastroenterology Diagnosis Differential Young Adult Internal medicine medicine Humans Mean corpuscular volume Genetics (clinical) Aged Aged 80 and over Anemia Iron-Deficiency medicine.diagnostic_test RED-CELL INDICES business.industry beta-Thalassemia Biochemistry (medical) Reproducibility of Results Red blood cell distribution width Hematology Iron deficiency Middle Aged Thailand medicine.disease Predictive value Red blood cell medicine.anatomical_structure Immunology Female business Biomarkers β thalassemia trait
Zdroj:	Hemoglobin. 39:235-239
ISSN:	1532-432X 0363-0269
DOI:	10.3109/03630269.2015.1048352
Popis:	β-Thalassemia (β-thal) and iron deficiency cause most microcytic anemias. Red cell indices and formulas have been established as simple, fast, and inexpensive in discrimination between these two hematological disorders in school children. However, whether these formulas could be applied to diagnose β-thal trait and iron deficiency in adult Thai subjects is unclear. The aim of this study was to examine the diagnostic accuracy of five red cell indices [red blood cell (RBC) counts, mean corpuscular volume (MCV), mean corpuscular hemoglobin (Hb) (MCH), mean corpuscular Hb concentration (MCHC), and red cell distribution width (RDW)] and nine formulas (RDW/RBC, RDW Index, Sirdah, Green and King, Mentzer, England and Fraser, Ehsani, Srivastava and Shine and Lal). Their sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPV), efficiency, and Youden's Index were analyzed in 102 β-thal trait and 64 iron deficiency adult Thai subjects. The RDW/RBC formula proved to be the most reliable index as they had 100.0% specificity and PPV and the highest efficiency (94.58%) and Youden's Index (91.18%), as well as high sensitivity (91.18%) and NPV (87.67%). Therefore, this formula could be used in initial discrimination of β-thal trait from iron deficiency in adult Thai subjects.
Databáze:	OpenAIRE
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