M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the Edge
| Autor: | Sofiane Y Mersaoui, Nivine Srour, Stéphane Richard |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Protein-Arginine N-Methyltransferases Cancer Research Dance Arginine Repressor Biology Methylation 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Humans Dancing Enzyme Inhibitors Protein arginine methyltransferase 5 Cancer Cell Biology medicine.disease 3. Good health Repressor Proteins 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research |
| Zdroj: | Cancer Cell. 36:3-5 |
| ISSN: | 1535-6108 |
| Popis: | In this issue of Cancer Cell, Fedoriw and colleagues characterize a potent reversible inhibitor of type I PRMTs, GSK3368715, with anti-proliferative effects on numerous cancer types. Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction needs to be achieved for synergistic anti-tumor activity. |
| Databáze: | OpenAIRE |
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