Cranial nerve damage in patients after alpha (heavy)-particle radiation to the pituitary
| Autor: | Wen C. Wei, Claude Y.L. Chong, James Price |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Nervous system
Adult Pituitary gland medicine.medical_treatment Reflex Pupillary Corneal Opacity Oculomotor Nerve medicine Dosimetry Humans Irradiation Trigeminal Nerve Radiation Injuries Abducens nerve Aged Diabetic Retinopathy Ophthalmoplegia business.industry Cranial Nerves Peripheral Nervous System Diseases Dose-Response Relationship Radiation Diabetic retinopathy Iridoplegia Middle Aged medicine.disease Alpha Particles Radiation therapy Ophthalmology medicine.anatomical_structure Pituitary Gland Nuclear medicine business |
| Zdroj: | Ophthalmology. 86(6) |
| ISSN: | 0161-6420 |
| Popis: | The records of 161 patients were reviewed to determine if radiation damage had occurred following cranial irradiation. All of these patients had received α-particle radiation to their pituitary glands during the period when this form of therapy was given for diabetic retinopathy. Extraocular muscle palsy developed in 11 of these patients, iridoplegia in six, and fifth nerve damage in six. All of the palsies developed within a short period following their irradiation, and a definite dose relationship was present. The dose rate was approximately 100 rads/min for all cases. Fractionation varied but it is known for all cases. The estimated doses to the third, fourth, fifth, and sixth cranial nerves was calculated at a saggital plane 13 to 15 mm from the pituitary by using computer-drawn dosimetry charts for the respective aperture size. The energetic α particles were produced by the 184-in synchrocyclotron at Berkeley, Calif. A dose relationship for radiation palsies was apparent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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