Endocytosis of Receptor Tyrosine Kinases
| Autor: | Lai Kuan Goh, Alexander Sorkin |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
animal structures
Endosome fungi Endocytic cycle Autophosphorylation Receptor Protein-Tyrosine Kinases Ubiquitination Signal transducing adaptor protein Endosomes Biology Endocytosis Models Biological General Biochemistry Genetics and Molecular Biology Receptor tyrosine kinase Protein Structure Tertiary Cell biology Protein Transport embryonic structures biology.protein Phosphorylation Tyrosine kinase Signal Transduction Perspectives |
| Zdroj: | Cold Spring Harbor Perspectives in Biology. 5:a017459-a017459 |
| ISSN: | 1943-0264 |
| DOI: | 10.1101/cshperspect.a017459 |
| Popis: | Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the cell surface and subsequent sorting of internalized ligand-RTK complexes to lysosomes for degradation. Activation of the intrinsic tyrosine kinase activity of RTKs results in autophosphorylation, which is mechanistically coupled to the recruitment of adaptor proteins and conjugation of ubiquitin to RTKs. Ubiquitination serves to mediate interactions of RTKs with sorting machineries both at the cell surface and on endosomes. The pathways and kinetics of RTK endocytic trafficking, molecular mechanisms underlying sorting processes, and examples of deviations from the standard trafficking itinerary in the RTK family are discussed in this work. |
| Databáze: | OpenAIRE |
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