Colposcopy accuracy in diagnosing cervical precancerous lesions in western Kazakhstan
| Autor: | Kanshaiym Sakiyeva, Dinara Zholmukhamedova, Andrea Tinelli, Olzhas Urazayev, Arip Koyshybaev, Saule Balmagambetova, Elnara Ismagulova, Saganaj T Djussembekov |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Human papillomavirus Reid index Reid colposcopy index lcsh:Gynecology and obstetrics lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Cytology medicine Case Series lcsh:RG1-991 Colposcopy 030219 obstetrics & reproductive medicine Cervical screening medicine.diagnostic_test business.industry Obstetrics Obstetrics and Gynecology Hpv screening Retrospective cohort study lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kazakhstan Oncology 030220 oncology & carcinogenesis Screening business Viral load |
| Zdroj: | Gynecologic Oncology Reports, Vol 34, Iss, Pp 100661-(2020) Gynecologic Oncology Reports |
| ISSN: | 2352-5789 |
| Popis: | Highlights • In the present case series study, colposcopy showed inferior efficiency in CIN2+ detection compared to cytology. • The sensitivity of colposcopy performance at HSIL was 56.6% vs. 89.6% for cytology. • The probability for HSIL occurrence increased up to 39.7 times at HPV viral load raising. • Outcomes of the study evidence the insufficiency of screening modality in Kazakhstan based on cytology and colposcopy only. This retrospective cohort study focused on colposcopic accuracy for the diagnosis of cervical premalignant lesions using cytology and histology, as well as HPV data not included in current cervical screening practices in Kazakhstan. Colposcopy performance was assessed using the modified Reid index in women aged 18–63 years. In total, 1,129 colposcopic-HPV-cytology triple samples and 94 histology findings were collected. The sensitivity of colposcopy was 81.6% with specificity 72.6% for LSIL but fell to 56.6% with specificity 88.3% for CIN2+ vs. 89.6% and 74.5% for cytology at CIN2+, respectively. The ORs for high-grade lesion occurrence within each colposcopy group at viral load rising vs. ORs for HPV-negative women were 3.4; 5.3; and 39.7, respectively (p |
| Databáze: | OpenAIRE |
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