Effects of racecadotril and loperamide on bacterial proliferation and on the central nervous system of the newborn gnotobiotic piglet

Autor:	P. Guillaume, Jeanne-Marie Lecomte, H. Berard, Y. Duval-Iflah, Y. Joulin, P. Baumer, P. Raibaud
Přispěvatelé:	Unité de recherche d'Écologie et Physiologie du Système Digestif (UEPSD), Institut National de la Recherche Agronomique (INRA), ProdInra, Migration
Rok vydání:	1999
Předmět:	Agonist Thiorphan medicine.medical_specialty Loperamide Swine medicine.drug_class [SDV]Life Sciences [q-bio] Racecadotril TUBE DIGESTIF Oral administration Internal medicine Animals Germ-Free Life Medicine Enkephalinase inhibitor Protease Inhibitors Pharmacology (medical) Antidiarrheals ACETORPHAN Bacteria Hepatology business.industry Stomach Gastroenterology Neurotoxicity Brain medicine.disease [SDV] Life Sciences [q-bio] medicine.anatomical_structure Endocrinology Animals Newborn Toxicity Neprilysin business Digestive System medicine.drug
Zdroj:	Alimentary Pharmacology and Therapeutics Alimentary Pharmacology and Therapeutics, Wiley, 1999, 13 (6), pp.09-14
ISSN:	0269-2813 1365-2036
DOI:	10.1046/j.1365-2036.1999.00001.x-i1
Popis:	Methods The effects of 4 days of oral administration of different doses of two drugs, an enkephalinase inhibitor (the antisecretory agent, racecadotril) and a μ-receptor agonist (loperamide), on intestinal growth of a bacterial nonpathogenic strain (Escherichia coli E 404) and on the central nervous system (CNS) were compared in newborn gnotobiotic piglets. Results The E. coli content of the proximal jejunum (segment S1) and the E. coli ratio of stomach:segment S1 were similar in the racecadotril (20 mg/kg b.d., n = 5) and control groups. In contrast, in the loperamide group (1 mg/kg b.d., n = 4), the E. coli content of segment S1 and the E. coli ratio stomach:S1 were both significantly higher than with racecadotril or control (P = 0.04 and 0.005, respectively, for E. coli content; P = 0.05 and 0.03, respectively, for stomach:S1). There were no clinical signs of neurotoxicity and no deaths with racecadotril given orally at a high dose of 130 mg/kg b.d. (n = 5) – nearly 60 times the paediatric dosage. In contrast, an equivalent high dose of loperamide (5 mg/kg b.d.) resulted in death in three out of four piglets. Conclusions In contrast to loperamide, racecadotril did not induce bacterial overgrowth and did not produce central neurotoxicity.
Databáze:	OpenAIRE
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