Association of TNF-α polymorphism rs1800629 with multisomatoform disorder in a group of German patients and healthy controls: An explorative study
| Autor: | Michael Bernateck, Dennis Buers, Matthias Karst, Lilly Volkmann, Lisa Pahl, Katharina C. Harms, Anh-Thu Tran, Karl P. Kapitza, Manfred Stuhrmann |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Immunology Polymorphism Single Nucleotide Biochemistry Proinflammatory cytokine Pathogenesis Germany Internal medicine Genotype medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Somatoform Disorders Molecular Biology Alleles Genetic Association Studies Demography Tumor Necrosis Factor-alpha business.industry Hematology Middle Aged Cytokine Haplotypes Case-Control Studies Etiology Female Lymphotoxin α Tumor necrosis factor alpha business |
| Zdroj: | Cytokine. 61:389-393 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2012.12.004 |
| Popis: | Introduction The etiology of multisomatoform disorder (MSD) is still largely unknown, but genetic factors seem to have an influence on pathogenesis. Pain is a major symptom of MSD and polymorphisms of different proinflammatory cytokines have been found associated with pain in former studies. Therefore, we presumed that cytokine polymorphisms could also be associated with MSD. Patients and methods Groups of 148 MSD patients with pain as the leading clinical symptom and 149 age and gender matched healthy controls participated in this study. Nine cytokine polymorphisms were genotyped and statistically analyzed for associations with MSD. Results Allelic and genotypic associations were found for rs16944 (interleukin 1β), rs1800629 (tumor necrosis factor) and rs909253 (lymphotoxin α). After correcting for multiple testing, the association of rs1800629 with MSD remained significant. The rare A-allele was correlated with MSD ( p = 0.007). Discussion Since the common G-allele of rs1800629 (TNFα) occurs much more often in the control group than in the MSD group it is assumed to be protective. Being carrier of the A-allele seems to be a risk factor for MSD. |
| Databáze: | OpenAIRE |
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