Two cases of secondary AA amyloidosis involving the skin and chronic kidney infection with a nephrotic syndrome in a high-income country
| Autor: | Florian Garo, Cedric Aglae, Olivier Moranne, Juliette Chatelain |
|---|---|
| Přispěvatelé: | Retiveau, Nolwenn, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Université de Montpellier (UM), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Nephrotic syndrome Renal function Case Report 030105 genetics & heredity Kidney Anasarca Gastroenterology 03 medical and health sciences 0302 clinical medicine AA amyloidosis Internal medicine MESH: Renal Insufficiency Edema Humans Medicine Renal medicine MESH: Amyloidosis Renal Insufficiency Public health MESH: Kidney Diseases [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology MESH: Humans MESH: Middle Aged business.industry Amyloidosis MESH: Kidney General Medicine Middle Aged Skin ulcer medicine.disease Nephrectomy MESH: Edema medicine.anatomical_structure Female Kidney Diseases MESH: Nephrotic Syndrome medicine.symptom business MESH: Female [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology 030217 neurology & neurosurgery |
| Zdroj: | BMJ Case Reports BMJ Case Reports, BMJ Publishing Group, 2021, 14 (6), pp.e239411. ⟨10.1136/bcr-2020-239411⟩ BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | International audience; We present two French cases of amyloid-associated (AA) amyloidosis secondary to chronic infections. Patient 1, a 51-year-old heroin addict, was hospitalised for chest pain and anasarca. During hospitalisation, a nephrotic syndrome with an inflammatory condition was discovered along with a chronic skin ulcer on his arm. Salivary gland and kidney biopsies confirmed the diagnosis of AA amyloidosis. Renal function quickly declined and haemodialysis was initiated 6 months later. Patient 2, a 55-year-old woman, was hospitalised for obstructive pyelonephritis secondary to coraliform lithiasis. Renal insufficiency with an impure nephrotic syndrome was found. After nephrectomy due to chronic pyelonephritis and an atrophic cortex on the abdominal scan, the histology revealed AA amyloidosis. Despite treatment with ACE inhibitors and control of inflammation, the nephrotic syndrome persisted with rapid decline of the kidney function. |
| Databáze: | OpenAIRE |
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