Effect of aldosterone on kinetics of intracellular sodium in cortical portion of collecting ducts in rat kidney
| Autor: | L. N. Ivanova, E. I. Solenov, N. S. Logvinenko |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Indoles Sodium Kinetics Intracellular Space chemistry.chemical_element In Vitro Techniques Fluorescence General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Sodium channel blocker Internal medicine medicine Animals Enzyme Inhibitors Kidney Tubules Collecting Aldosterone Protein Kinase C Protein kinase C Kidney Renal sodium reabsorption Chemistry General Medicine Rats Amiloride medicine.anatomical_structure Endocrinology Microdissection medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 146:192-195 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-008-0242-z |
| Popis: | We studied the effect of protein kinase C inhibitor RO-31-8220 (10(-7) M) on rapid nongenomic effect of aldosterone in cells of isolated segment of distal region of collecting duct in rat kidney. Experiments with fluorescent dye Na-Green showed that the inhibitor abolished the modulating effect of aldosterone (10 nM) on intracellular sodium concentration at external sodium concentration of 14 mM. Aldosterone decreased by half the initial rate of the changes in internal sodium concentration in both 10-day and mature rats (p0.05). Similarly to sodium channel blocker amiloride (10(-5) M), RO-31-8220 abolished rapid nongenomic effect of aldosterone on the rate of the changes in internal sodium concentration. |
| Databáze: | OpenAIRE |
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