Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases
Autor: | Ilda Patrícia Ribeiro, Isabel M. Carreira, Francisco Batel Marques, Joana B. Melo, Leonor Barroso, Joana Rodrigues, Francisco Caramelo |
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Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine malignant transformation Cancer Research Pathology medicine.medical_specialty Biology Malignancy Biochemistry oral leukoplakia oral carcinoma Malignant transformation 03 medical and health sciences 0302 clinical medicine Chromosomal Instability Genetics medicine Carcinoma Humans Glucuronosyltransferase oral erythroleukoplakia Molecular Biology Aged Neoplasm Staging Leukoplakia Mouth neoplasm Comparative Genomic Hybridization genomic imbalances F-Box Proteins Nuclear Proteins Ubiquitin-Protein Ligase Complexes biomarkers Cancer Genomics Articles Middle Aged Erythromelalgia medicine.disease Primary tumor stomatognathic diseases 030104 developmental biology Oncology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Molecular Medicine Mouth Neoplasms Comparative genomic hybridization |
Zdroj: | Molecular Medicine Reports |
ISSN: | 1791-3004 1791-2997 |
Popis: | Oral leukoplakia and erythroleukoplakia are common oral potentially malignant disorders diagnosed in the oral cavity. The specific outcome of these lesions remains to be elucidated, as their malignant transformation rate exhibits great variation. The ability to predict which of those potentially malignant lesions are likely to progress to cancer would be vital to guide their future clinical management. The present study reported two patients with tongue squamous cell carcinoma: Case study 1 was diagnosed with a simultaneous leukoplakia and case study 2 developed an erythroleukoplakia following the primary tumor treatment. Whole genome copy number alterations were analyzed using array comparative genomic hybridization. The present study determined more genomic imbalances in the tissues from leukoplakia and erythroleukoplakia compared with their respective tumors. The present study also identified in tumor and potentially malignant lesions common alterations of chromosomal regions and genes, including FBXL5, UGT2B15, UGT2B28, KANSL1, GSTT1 and DUSP22, being some of these typical aberrations described in oral cancer and others are linked to chemoradioresistance. Several putative genes associated with hallmarks of malignancy that may have an important role in predicting the progression of leukoplakia and erythroleukoplakia to squamous cell carcinoma, namely gains in BNIPL, MCL1, STAG2, CSPP1 and ZNRF3 genes were also identified. |
Databáze: | OpenAIRE |
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