Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases

Autor: Ilda Patrícia Ribeiro, Isabel M. Carreira, Francisco Batel Marques, Joana B. Melo, Leonor Barroso, Joana Rodrigues, Francisco Caramelo
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
malignant transformation
Cancer Research
Pathology
medicine.medical_specialty
Biology
Malignancy
Biochemistry
oral leukoplakia
oral carcinoma
Malignant transformation
03 medical and health sciences
0302 clinical medicine
Chromosomal Instability
Genetics
medicine
Carcinoma
Humans
Glucuronosyltransferase
oral erythroleukoplakia
Molecular Biology
Aged
Neoplasm Staging
Leukoplakia
Mouth neoplasm
Comparative Genomic Hybridization
genomic imbalances
F-Box Proteins
Nuclear Proteins
Ubiquitin-Protein Ligase Complexes
biomarkers
Cancer
Genomics
Articles
Middle Aged
Erythromelalgia
medicine.disease
Primary tumor
stomatognathic diseases
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Cancer research
Molecular Medicine
Mouth Neoplasms
Comparative genomic hybridization
Zdroj: Molecular Medicine Reports
ISSN: 1791-3004
1791-2997
Popis: Oral leukoplakia and erythroleukoplakia are common oral potentially malignant disorders diagnosed in the oral cavity. The specific outcome of these lesions remains to be elucidated, as their malignant transformation rate exhibits great variation. The ability to predict which of those potentially malignant lesions are likely to progress to cancer would be vital to guide their future clinical management. The present study reported two patients with tongue squamous cell carcinoma: Case study 1 was diagnosed with a simultaneous leukoplakia and case study 2 developed an erythroleukoplakia following the primary tumor treatment. Whole genome copy number alterations were analyzed using array comparative genomic hybridization. The present study determined more genomic imbalances in the tissues from leukoplakia and erythroleukoplakia compared with their respective tumors. The present study also identified in tumor and potentially malignant lesions common alterations of chromosomal regions and genes, including FBXL5, UGT2B15, UGT2B28, KANSL1, GSTT1 and DUSP22, being some of these typical aberrations described in oral cancer and others are linked to chemoradioresistance. Several putative genes associated with hallmarks of malignancy that may have an important role in predicting the progression of leukoplakia and erythroleukoplakia to squamous cell carcinoma, namely gains in BNIPL, MCL1, STAG2, CSPP1 and ZNRF3 genes were also identified.
Databáze: OpenAIRE
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